2019 年冠状病毒病时代的人类免疫缺陷病毒/艾滋病：两种大流行病的并置。
Human Immunodeficiency Virus/AIDS in the Era of Coronavirus Disease 2019: A Juxtaposition of 2 Pandemics.
机构信息
Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
J Infect Dis. 2021 Nov 16;224(9):1455-1461. doi: 10.1093/infdis/jiab114.
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted persons with human immunodeficiency virus (HIV), interfering with critical health services for HIV prevention, treatment, and care. While there are multiple profiles of persons living with HIV and the impact of COVID-19 may differ for each, the severity of COVID-19 in persons with HIV is related strongly to the presence of comorbidities that increase the risk of severe disease in COVID-19 patients in the absence of HIV. An effective response to the juxtaposition of the HIV and COVID-19 pandemics requires a novel coordinated and collaborative global effort of scientists, industry, and community partners to accelerate basic and clinical research, as well as implementation science to operationalize evidence-based interventions expeditiously in real-world settings. Accelerated development and clinical evaluation of prevention and treatment countermeasures are urgently needed to mitigate the juxtaposition of the HIV and COVID-19 pandemics.
摘要
2019 年冠状病毒病（COVID-19）大流行对人类免疫缺陷病毒（HIV）感染者产生了重大影响，干扰了 HIV 预防、治疗和护理的关键卫生服务。虽然 HIV 感染者有多种类型，COVID-19 的影响可能因个体而异，但 HIV 感染者 COVID-19 的严重程度与合并症密切相关，这些合并症增加了 COVID-19 患者在没有 HIV 的情况下患重病的风险。有效应对 HIV 和 COVID-19 大流行的并置需要科学家、工业界和社区合作伙伴进行新型协调和协作的全球努力，以加速基础和临床研究，以及实施科学，以便在实际环境中迅速实施基于证据的干预措施。迫切需要加快预防和治疗对策的开发和临床评估，以减轻 HIV 和 COVID-19 大流行的并置。
相似文献
1
Human Immunodeficiency Virus/AIDS in the Era of Coronavirus Disease 2019: A Juxtaposition of 2 Pandemics.2019 年冠状病毒病时代的人类免疫缺陷病毒/艾滋病：两种大流行病的并置。
J Infect Dis. 2021 Nov 16;224(9):1455-1461. doi: 10.1093/infdis/jiab114.
2
Triple Burden: The Incorrigible Threat of Tuberculosis, HIV, and COVID-19.三重负担：结核病、艾滋病病毒和 COVID-19 的不治之症威胁。
Infect Disord Drug Targets. 2024;24(4):1-7. doi: 10.2174/0118715265259959231031104820.
3
Reflections on 40 Years of AIDS.艾滋病 40 年反思。
Emerg Infect Dis. 2021 Jun;27(6):1553-1560. doi: 10.3201/eid2706.210284.
4
The syndemic burden of HIV/AIDS in Africa amidst the COVID-19 pandemic.非洲在 COVID-19 大流行期间艾滋病的联合流行负担。
Immun Inflamm Dis. 2022 Jan;10(1):26-32. doi: 10.1002/iid3.544. Epub 2021 Oct 4.
5
[HIV and COVID-19: two viral pandemics in interaction].[艾滋病病毒与新型冠状病毒肺炎：两种相互作用的病毒性大流行]
Rev Med Suisse. 2022 Jan 19;18(764-5):74-80. doi: 10.53738/REVMED.2022.18.764-65.74.
6
COVID-19: Learning from the HIV/AIDS pandemic response in Africa.新冠疫情：从非洲艾滋病大流行应对中学到的经验。
Int J Health Plann Manage. 2021 May;36(3):610-617. doi: 10.1002/hpm.3133. Epub 2021 Feb 24.
7
The COVID-19, tuberculosis and HIV/AIDS: Ménage à Trois.新型冠状病毒肺炎、结核病和艾滋病：三者之间的关系。
Front Immunol. 2023 Jan 27;14:1104828. doi: 10.3389/fimmu.2023.1104828. eCollection 2023.
8
Transient Reductions in Human Immunodeficiency Virus (HIV) Clinic Attendance and Food Security During the Coronavirus Disease 2019 (COVID-19) Pandemic for People Living With HIV in 4 African Countries.在 4 个非洲国家，艾滋病毒感染者在 2019 冠状病毒病（COVID-19）大流行期间，艾滋病毒诊所就诊和粮食保障的短暂减少。
Clin Infect Dis. 2021 Nov 16;73(10):1901-1905. doi: 10.1093/cid/ciab379.
9
HIV/Aids and COVID-19 in Brazil: in four decades, two antithetical approaches to face serious pandemics.巴西的艾滋病毒/艾滋病和 COVID-19：四十年间，两种截然相反的方法应对严重的大流行病。
Mem Inst Oswaldo Cruz. 2021 Jun 21;116:e210071. doi: 10.1590/0074-02760210071. eCollection 2021.
10
COVID-19 & HIV/AIDS pandemics: Parallels & lessons.新冠疫情与艾滋病疫情：相似之处与教训
Indian J Med Res. 2021;153(1 & 2):214-218. doi: 10.4103/ijmr.IJMR_2598_20.
引用本文的文献
1
Evaluating the mediating effect of behavioural and biological practices in the relationship between sociostructural risk factors and HIV infection outcomes among Adolescent Girls and Young Women: a cross-sectional study in central Uganda.评估行为和生物学行为在社会结构风险因素与乌干达中部少女和青年女性艾滋病毒感染结果之间关系中的中介作用：一项横断面研究
BMC Public Health. 2025 Jun 10;25(1):2141. doi: 10.1186/s12889-025-23395-8.
2
A cross-section study of the relationship between lifestyles and severity of COVID-19 symptoms in people living with HIV.一项关于HIV感染者生活方式与COVID-19症状严重程度之间关系的横断面研究。
Sci Rep. 2025 May 20;15(1):17464. doi: 10.1038/s41598-025-99528-1.
3
Managing and assembling population-scale data streams, tools and workflows to plan for future pandemics within the INFORM-Africa Consortium.在“非洲信息行动”（INFORM-Africa）联盟内管理和整合大规模人口数据流、工具及工作流程，以规划应对未来的大流行病。
S Afr J Sci. 2023 May-Jun;119(5-6). doi: 10.17159/sajs.2023/14659. Epub 2023 May 30.
4
-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants.取代的双环氨基甲酰基吡啶酮：整合酶链转移抑制剂，能有效抑制耐药 HIV-1 整合酶突变体。
ACS Infect Dis. 2024 Mar 8;10(3):917-927. doi: 10.1021/acsinfecdis.3c00525. Epub 2024 Feb 12.
5
Reduced HIV/AIDS diagnosis rates and increased AIDS mortality due to late diagnosis in Brazil during the COVID-19 pandemic.巴西在新冠大流行期间因延迟诊断导致 HIV/AIDS 诊断率降低和艾滋病死亡率增加。
Sci Rep. 2023 Dec 27;13(1):23003. doi: 10.1038/s41598-023-50359-y.
6
Dynamics of temporal immune responses in nonhuman primates and humans immunized with COVID-19 vaccines.COVID-19 疫苗接种的非人类灵长类动物和人类的时间免疫反应动力学。
PLoS One. 2023 Oct 19;18(10):e0287377. doi: 10.1371/journal.pone.0287377. eCollection 2023.
7
Immunogenicity and Efficacy of Vaccination in People Living with Human Immunodeficiency Virus.人类免疫缺陷病毒感染者接种疫苗的免疫原性和疗效
Viruses. 2023 Aug 30;15(9):1844. doi: 10.3390/v15091844.
8
Recent Advances in Conjugated Polymer-Based Biosensors for Virus Detection.基于共轭聚合物的生物传感器在病毒检测中的最新进展。
Biosensors (Basel). 2023 May 28;13(6):586. doi: 10.3390/bios13060586.
9
Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir.针对HIV-1整合酶链转移抑制剂多替拉韦、比克替拉韦和卡博特韦共有的关键吡啶酮羧酸前体的合成方法。
Org Process Res Dev. 2023 Apr 20;27(5):847-853. doi: 10.1021/acs.oprd.3c00063. eCollection 2023 May 19.
10
The (Contrasted) Ethics of Covid-19 and HIV: Will the Favor be Returned?新冠病毒与艾滋病毒的（对比）伦理学：这份善意会得到回报吗？
J Healthc Sci Humanit. 2021 Fall;11(1):107-121.
本文引用的文献
1
COVID-19 in Immunocompromised Hosts: What We Know So Far.免疫功能低下宿主中的 COVID-19：目前我们已知的情况。
Clin Infect Dis. 2021 Jan 27;72(2):340-350. doi: 10.1093/cid/ciaa863.
2
Perceived Interruptions to HIV Prevention and Treatment Services Associated With COVID-19 for Gay, Bisexual, and Other Men Who Have Sex With Men in 20 Countries.20 个国家的男同性恋者、双性恋者和其他与男性发生性关系者对与 COVID-19 相关的艾滋病毒预防和治疗服务中断的看法。
J Acquir Immune Defic Syndr. 2021 May 1;87(1):644-651. doi: 10.1097/QAI.0000000000002620.
3
When Epidemics Collide: Why People With Human Immunodeficiency Virus May Have Worse Coronavirus Disease 2019 Outcomes and Implications for Vaccination.当流行病碰撞：为何人类免疫缺陷病毒感染者的2019冠状病毒病预后可能更差及对疫苗接种的影响
Clin Infect Dis. 2021 Jun 15;72(12):e1030-e1034. doi: 10.1093/cid/ciaa1946.
4
HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform.HIV 感染与 COVID-19 死亡：基于人群的英国初级保健数据队列分析及 OpenSAFELY 平台内的全国死亡登记数据关联分析
Lancet HIV. 2021 Jan;8(1):e24-e32. doi: 10.1016/S2352-3018(20)30305-2. Epub 2020 Dec 11.
5
Coronavirus Disease 2019 (COVID-19) Infection Among People With Human Immunodeficiency Virus in New York City: A Population-Level Analysis of Linked Surveillance Data.新型冠状病毒病 2019（COVID-19）在纽约市人类免疫缺陷病毒感染者中的感染：基于关联监测数据的人群水平分析。
Clin Infect Dis. 2021 Jun 15;72(12):e1021-e1029. doi: 10.1093/cid/ciaa1793.
6
Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study.在 ISARIC 世界卫生组织（WHO）临床特征协议（英国）中，人类免疫缺陷病毒（HIV）感染者因 2019 年冠状病毒病（COVID-19）相关住院的结果：一项前瞻性观察研究。
Clin Infect Dis. 2021 Oct 5;73(7):e2095-e2106. doi: 10.1093/cid/ciaa1605.
7
Impact of COVID-19 on people living with HIV: A review.2019冠状病毒病对艾滋病毒感染者的影响：综述
J Virus Erad. 2020 Nov;6(4):100019. doi: 10.1016/j.jve.2020.100019. Epub 2020 Oct 15.
8
Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients With Human Immunodeficiency Virus and Coronavirus Disease 2019.一项关于人类免疫缺陷病毒和 2019 冠状病毒病患者的多中心注册研究的特征、合并症和结局。
Clin Infect Dis. 2021 Oct 5;73(7):e1964-e1972. doi: 10.1093/cid/ciaa1339.
9
SARS-CoV-2 infection in people living with HIV: a systematic review.SARS-CoV-2 感染人类免疫缺陷病毒（HIV）感染者：一项系统综述。
Rev Med Virol. 2021 Jan;31(1):1-12. doi: 10.1002/rmv.2155. Epub 2020 Sep 1.
10
Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships.肥胖与 COVID-19 患者：流行病学和生物学关系的全球视角。
Obes Rev. 2020 Nov;21(11):e13128. doi: 10.1111/obr.13128. Epub 2020 Aug 26.
Zotero 插件