Allard Antoine, Lopes Dos Santos Rogério, Campillo Clément
LAMBE, Université d'Évry, CNRS, CEA, Université Paris-Saclay, Évry-Courcouronnes, 91025, France.
Sorbonne Université, UPMC, Paris 06, Paris, France.
Biol Cell. 2021 Aug;113(8):329-343. doi: 10.1111/boc.202000148. Epub 2021 Apr 30.
Inside living cells, the remodelling of membrane tubules by actomyosin networks is crucial for processes such as intracellular trafficking or organelle reshaping. In this review, we first present various in vivo situations in which actin affects membrane tubule remodelling, then we recall some results on force production by actin dynamics and on membrane tubules physics. Finally, we show that our knowledge of the underlying mechanisms by which actomyosin dynamics affect tubule morphology has recently been moved forward. This is thanks to in vitro experiments that mimic cellular membranes and actin dynamics and allow deciphering the physics of tubule remodelling in biochemically controlled conditions, and shed new light on tubule shape regulation.
在活细胞内部，肌动蛋白-肌球蛋白网络对膜小管的重塑对于细胞内运输或细胞器重塑等过程至关重要。在这篇综述中，我们首先介绍肌动蛋白影响膜小管重塑的各种体内情况，然后回顾一些关于肌动蛋白动力学产生力以及膜小管物理学的研究结果。最后，我们表明，最近我们对肌动蛋白-肌球蛋白动力学影响小管形态的潜在机制的认识取得了进展。这得益于体外实验，这些实验模拟细胞膜和肌动蛋白动力学，能够在生化可控条件下解读小管重塑的物理学原理，并为小管形状调控提供了新的见解。
