Khokhlov A P, Iarygin K N
Biull Eksp Biol Med. 1988 May;105(5):545-7.
Specific binding of gamma-(4 hydroxy-3,5-ditret. butyl-phenol) propionate (phenozan), a synthetic water-soluble screened phenol with antioxidant activity, with isolated rat enterocytes has been demonstrated. The Scatchard analysis of binding isotherms revealed two types of 3H-phenozan binding sites. It is concluded that the effect of synthetic screened phenol antioxidants on cellular activity is the result of two mechanisms of action--alteration of physicochemical properties of membrane lipids caused by the inhibitors of free-radical reactions and specific binding of these compounds to cell plasma membranes.
已证实，γ-（4-羟基-3,5-二叔丁基苯酚）丙酸酯（酚赞），一种具有抗氧化活性的合成水溶性筛选酚，与分离的大鼠肠上皮细胞有特异性结合。结合等温线的Scatchard分析揭示了两种类型的3H-酚赞结合位点。得出的结论是，合成筛选酚抗氧化剂对细胞活性的影响是两种作用机制的结果——自由基反应抑制剂引起的膜脂物理化学性质改变以及这些化合物与细胞质膜的特异性结合。
