使用 DIAMOND 进行生命之树尺度上的敏感蛋白质比对。
Sensitive protein alignments at tree-of-life scale using DIAMOND.
机构信息
Computational Biology Group, Max Planck Institute for Developmental Biology, Tübingen, Germany.
Max Planck Computing and Data Facility, Garching, Germany.
出版信息
Nat Methods. 2021 Apr;18(4):366-368. doi: 10.1038/s41592-021-01101-x. Epub 2021 Apr 7.
We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.
我们正处于基因组学革命的开端，计划对所有已知物种进行测序。在这个数据驱动的生物学新时代，获取这些数据进行比较分析至关重要。在这里，我们介绍了 DIAMOND 的一个改进版本，它大大超过了以前的搜索性能，并利用超级计算机在数小时内执行生命之树规模的蛋白质比对，同时匹配黄金标准 BLASTP 的灵敏度。
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