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通过DNA链分离产生细菌多样性

Generation of Bacterial Diversity by Segregation of DNA Strands.

作者信息

Norris Vic, Ripoll Camille

机构信息

Laboratory of Microbiology Signals and Microenvironment, Faculty of Science, University of Rouen, Mont Saint Aignan, France.

Faculty of Science, University of Rouen, Mont Saint Aignan, France.

出版信息

Front Microbiol. 2021 Mar 22;12:550856. doi: 10.3389/fmicb.2021.550856. eCollection 2021.

DOI:10.3389/fmicb.2021.550856
PMID:33828535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8019907/
Abstract

The generation in a bacterial population of a diversity that is coherent with present and future environments is a fundamental problem. Here, we use modeling to investigate growth rate diversity. We show that the combination of (1) association of extended assemblies of macromolecules with the DNA strands and (2) the segregation of DNA strands during cell division allows cells to generate different patterns of growth rate diversity with little effect on the overall growth rate of the population and thereby constitutes an example of "order for free" on which evolution can act.

摘要

在细菌群体中产生与当前和未来环境相适应的多样性是一个基本问题。在此，我们使用建模方法来研究生长速率多样性。我们表明，（1）大分子的延伸组装体与DNA链的结合以及（2）细胞分裂过程中DNA链的分离这两者的结合，使得细胞能够产生不同模式的生长速率多样性，而对群体的总体生长速率影响很小，从而构成了一种“免费的秩序”的例子，进化可以作用于其上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/2889a1b126b0/fmicb-12-550856-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/be4f6f43c47e/fmicb-12-550856-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/b63b8e510b81/fmicb-12-550856-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/1fd5fb7a12c9/fmicb-12-550856-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/2889a1b126b0/fmicb-12-550856-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/be4f6f43c47e/fmicb-12-550856-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/b63b8e510b81/fmicb-12-550856-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/1fd5fb7a12c9/fmicb-12-550856-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/971f/8019907/2889a1b126b0/fmicb-12-550856-g004.jpg

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本文引用的文献

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The common misuse of noise decomposition as applied to genetic systems.常见的遗传系统中噪声分解的误用。
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Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid-liquid phase separation.
Life (Basel). 2023 Sep 10;13(9):1890. doi: 10.3390/life13091890.
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The Ring World: Eversion of Small Double-Stranded Polynucleotide Circlets at the Origin of DNA Double Helix, RNA Polymerization, Triplet Code, Twenty Amino Acids, and Strand Asymmetry.环形世界：DNA 双螺旋、RNA 聚合酶、三联体密码、二十个氨基酸和链不对称性起源时的小型双链短链环的反转。
Int J Mol Sci. 2022 Oct 26;23(21):12915. doi: 10.3390/ijms232112915.
细菌 RNA 聚合酶簇是通过液-液相分离组装而成的生物分子凝聚物。
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18540-18549. doi: 10.1073/pnas.2005019117. Epub 2020 Jul 16.
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Quantitation and Comparison of Phenotypic Heterogeneity Among Single Cells of Monoclonal Microbial Populations.单克隆微生物群体单细胞表型异质性的定量与比较
Front Microbiol. 2019 Dec 20;10:2814. doi: 10.3389/fmicb.2019.02814. eCollection 2019.
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DEAD-box ATPases are global regulators of phase-separated organelles.DEAD-box ATPases 是相分离细胞器的全局调节因子。
Nature. 2019 Sep;573(7772):144-148. doi: 10.1038/s41586-019-1502-y. Epub 2019 Aug 21.
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