Alkan Özer, Kaya Yeşim, Yüksek Esra, Kömüroglu Ahmet Ufuk
Department of Orthodontics, Ankara Yıldırım Beyazıt University Faculty of Dentistry, Ankara, Turkey.
Department of Orthodontics, Yuzuncu Yıl University Faculty of Dentistry, Van, Turkey.
Turk J Orthod. 2021 Mar 1;34(1):26-30. doi: 10.5152/TurkJOrthod.2021.20049. eCollection 2021.
This study aims to evaluate the effect of low-level laser therapy on peri-miniscrew fluid prostaglandin E2 (PGE2) and substance P (SP) levels during orthodontic treatment.
A total of 15 individuals were included in this study. Miniscrews were inserted to the inter-radicular region of the maxillary right and left second premolar and the first molar teeth, and diode lasers were randomly applied to the right or left side. Irradiation was performed at 940 nm wavelength using a gallium-aluminum-arsenide diode laser with 100 mW power output, 0.125 cm2 spectral area, 8 J/cm2 energy density, and 10 seconds of exposure time. Peri-miniscrew fluid samples were collected on the 1st, 3rd, and 7th days, and PGE2 and SP levels were assessed. For statistical comparison, two-way (factors) analysis of variance with repeated measurements on one-factor levels was used at statistical significance (p) of <0.05.
PGE2 levels on the 1st, 3rd, and 7th days were 160.64±10.05, 135.17±37.18, and 98.57±22.94, respectively, in the control group and 150.75±9.08, 87.17±40.67, and 78.10±16.50, respectively, in the laser group. SP levels on the 1st, 3rd, and 7th days were 79.90±12.05, 64.61±10.05, and 70.05±9.10, respectively, in the control group and 76.32±11.39, 60.25±9.08, and 65.71±5.59, respectively, in the laser group. The differences in PGE2 and SP levels between the laser and control groups were not statistically significant at all time intervals.
Low-level laser therapy cannot be recommended as a clinical adjunct therapy to reduce inflammation and pain around the miniscrews.
本研究旨在评估低强度激光治疗对正畸治疗期间微型螺钉周围组织液中前列腺素E2（PGE2）和P物质（SP）水平的影响。
本研究共纳入15名个体。在上颌左右第二前磨牙和第一磨牙的根间区域植入微型螺钉，并将二极管激光随机应用于右侧或左侧。使用输出功率为100 mW、光谱面积为0.125 cm2、能量密度为8 J/cm2、照射时间为10秒的砷化镓铝二极管激光在940 nm波长下进行照射。在第1、3和7天采集微型螺钉周围组织液样本，并评估PGE2和SP水平。为进行统计学比较，采用单因素水平重复测量的双向（因素）方差分析，显著性水平（p）<0.05。
对照组第1、3和7天的PGE2水平分别为160.64±10.05、135.17±37.18和98.57±22.94，激光组分别为150.75±9.08、87.17±40.67和78.10±16.50。对照组第1、3和7天的SP水平分别为79.90±12.05、64.61±10.05和70.05±9.10，激光组分别为76.32±11.39、60.25±9.08和65.71±5.59。在所有时间间隔内，激光组和对照组之间的PGE2和SP水平差异均无统计学意义。
不建议将低强度激光治疗作为减少微型螺钉周围炎症和疼痛的临床辅助治疗方法。
