Yassaei Soghra, Kordi Somayeh, Aghili Hosseinagha, Zavar Reza Javad, Ebrahiminik Zahra
Department of Orthodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Private Practice, Sari, Iran.
J Lasers Med Sci. 2023 Feb 12;14:e3. doi: 10.34172/jlms.2023.03. eCollection 2023.
This study aimed to assess the effect of low-level laser therapy (LLLT) on miniscrew stability and concentrations of interleukin-1β (IL-1β) and transforming growth factor-beta (TGF-β1) in peri-miniscrew crevicular fluid in the course of orthodontic treatment. This randomized split-mouth double-blind clinical trial evaluated 18 patients requiring anterior retraction along with maximum anchorage. Miniscrews were placed between the maxillary second premolar and first molar. A diode laser was irradiated with a 980-nm wavelength and 100-mW output power in continuous-wave mode at four time points: T0 (1 hour after miniscrew placement), T1 (1 week later), T2 (at 1 month) and T3 (at 3 months) in one quadrant of the maxilla (laser group). The other quadrant of the maxilla underwent the pseudo-application of the laser (control group). The primary stability of miniscrews was measured by Periotest M and reported as Periotest value (PTV). Also, at each time point, samples were collected from the peri-miniscrew crevicular fluid one hour after laser irradiation to assess the concentration of IL-1β and TGF-β1. The mean PTV (inverse of the stability) was smaller in the laser group compared with the control group at all time points; this difference was significant at T2 and T3. The mean concentration of IL-1β in the laser group was lower than that in the control group at all time points, and this difference was significantly remarkable at T0 and T3. The mean concentration of TGF-β1 in the laser group was lower than that in the control group at T0, T1 and T3; however, the difference was not statistically significant. The current results supported the efficacy of LLLT in increasing the miniscrew stability and decreasing the level of IL-1β pro-inflammatory cytokine.
本研究旨在评估低强度激光疗法（LLLT）对正畸治疗过程中微型螺钉稳定性以及微型螺钉周围龈沟液中白细胞介素-1β（IL-1β）和转化生长因子-β1（TGF-β1）浓度的影响。这项随机分组双盲临床试验评估了18例需要上颌前牙内收并采用强支抗的患者。微型螺钉植入上颌第二前磨牙和第一磨牙之间。在一个上颌象限（激光组）的四个时间点：T0（微型螺钉植入后1小时）、T1（1周后）、T2（1个月时）和T3（3个月时），使用波长980 nm、输出功率100 mW的连续波模式二极管激光进行照射。上颌的另一象限接受激光模拟照射（对照组）。用Periotest M测量微型螺钉的初始稳定性，并以Periotest值（PTV）报告。此外，在每个时间点，于激光照射1小时后从微型螺钉周围龈沟液中采集样本，以评估IL-1β和TGF-β1的浓度。在所有时间点，激光组的平均PTV（稳定性的倒数）均低于对照组；在T2和T3时，这种差异具有统计学意义。在所有时间点，激光组IL-1β的平均浓度均低于对照组，在T0和T3时，这种差异非常显著。在T0、T1和T3时，激光组TGF-β1的平均浓度低于对照组；然而，差异无统计学意义。目前的结果支持低强度激光疗法在提高微型螺钉稳定性和降低促炎细胞因子IL-1β水平方面的有效性。
