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妊娠期间嗜铬细胞瘤的误诊表现:一例报告

A Misleading Presentation of Pheochromocytoma in Pregnancy: A Case Report.

作者信息

Begum Jasmina, Kumari Supriya, Ali Manwar, Kumar Jena Saubhagya, Behera Kishore, Mishra Pritinanda

机构信息

All India Institute of Medical Sciences, Department of Obstetrics and Gynecology, Bhubaneswar, India.

All India Institute of Medical Sciences, Department of General Surgery, Bhubaneswar, India.

出版信息

Medeni Med J. 2021;36(1):69-74. doi: 10.5222/MMJ.2021.29660. Epub 2021 Mar 26.

Abstract

Pheochromocytoma is a catecholamine-secreting adrenal tumor and also a rare cause of secondary hypertension in pregnancy. Its low prevalence, nonspecific clinical presentation, and symptoms similar to preeclampsia generate a diagnostic challenge during pregnancy. A 23-year-old hypertensive pregnant woman at 36th gestational week of her first pregnancy was admitted with severe hypertension (210/150 mmHg), headache and proteinuria that made us presume the case as severe preeclampsia. In spite of starting with maximum doses of antihypertensive medications like IV labetolol,and oral nifedipine, loading dose of an anticonvulsant drug, and IV magnesium sulphate, her symptoms persisted. Keeping in view the risks involved to mother and fetus, we delivered the baby by emergency cesarean section. In the postoperative period, along with severe uncontrolled hypertension, she developed tremors, palpitation, and sweating that all led us to further diagnostic workup for secondary causes of hypertension. Eventually, a diagnosis of pheochromocytoma was confirmed by abdominopelvic contrast- enhanced computed tomography and by increased 24-hour urine metanephrine, normetanephrine, and vanillylmandelic acid levels. Subsequently, adrenal suppression was achieved by a multidisciplinary approach, and then she underwent laparoscopic adrenalectomy. This case highlights the importance of maintaining a high index of suspicion and multidisciplinary approach while investigating secondary causes of hypertension in young women, thereby differentiating it from preeclampsia.

摘要

嗜铬细胞瘤是一种分泌儿茶酚胺的肾上腺肿瘤,也是妊娠期继发性高血压的罕见病因。其低发病率、非特异性临床表现以及与子痫前期相似的症状,在孕期引发了诊断难题。一名23岁的初产妇,孕36周,因重度高血压(210/150 mmHg)、头痛和蛋白尿入院,这使我们推测该病例为重度子痫前期。尽管开始使用了最大剂量的降压药物,如静脉注射拉贝洛尔和口服硝苯地平,以及抗惊厥药物的负荷剂量和静脉注射硫酸镁,但她的症状仍持续存在。考虑到对母亲和胎儿的风险,我们通过急诊剖宫产分娩了婴儿。术后,除了严重的难以控制的高血压外,她还出现了震颤、心悸和出汗,所有这些都促使我们对高血压的继发性病因进行进一步的诊断检查。最终,通过腹盆腔增强计算机断层扫描以及24小时尿间甲肾上腺素、去甲间甲肾上腺素和香草扁桃酸水平升高,确诊为嗜铬细胞瘤。随后,通过多学科方法实现了肾上腺抑制,然后她接受了腹腔镜肾上腺切除术。该病例强调了在调查年轻女性高血压继发性病因时保持高度怀疑指数和采用多学科方法的重要性,从而将其与子痫前期区分开来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d60b/8020182/4767728224b1/MEDJ-36-069-f1.jpg

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