Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, People's Republic of China.
Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China, 646000.
Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3493-3501. doi: 10.1007/s00259-021-05343-x. Epub 2021 Apr 7.
Renal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolonging patient survival. Renal puncture examination is the gold standard for renal fibrosis, but it has several limitations. This study aims to evaluate the diagnostic performance of a novel PET radiotracer, [Ga]Ga-fibroblast activation protein inhibitor (FAPI)-04, which specifically images fibroblast activation protein (FAP) expression for renal fibrosis.
All patients underwent renal puncture before receiving [Ga]Ga-FAPI-04 PET/CT imaging. They then underwent [Ga]Ga-FAPI-04 PET/CT and immunochemistry examinations. The data obtained were analyzed.
The [Ga]Ga-FAPI-04 PET/CT examination results demonstrated that almost all patients (12/13) exhibited increased radiotracer uptake. The maximum standardized uptake value (SUVmax) in patients with mild, moderate, and severe fibrosis was 3.92 ± 1.50, 5.98 ± 1.6, and 7.67 ± 2.23, respectively.
Compared with renal puncture examination, non-invasive imaging of FAP expression through [Ga]Ga-FAPI-04 PET/CT quickly demonstrates bilateral kidney conditions with high sensitivity. [Ga]Ga-FAPI-04 PET/CT can facilitate the evaluation of disease progression, diagnosis, and the development of a treatment plan.
肾纤维化是慢性肾脏病进展过程中的一种病理状态。早期发现和治疗对于延长患者的生存时间至关重要。肾穿刺检查是肾纤维化的金标准，但它存在一些局限性。本研究旨在评估一种新型 PET 放射性示踪剂 [Ga]Ga-成纤维细胞激活蛋白抑制剂（FAPI）-04 的诊断性能，该示踪剂特异性地对成纤维细胞激活蛋白（FAP）表达进行成像，用于肾纤维化的诊断。
所有患者在接受 [Ga]Ga-FAPI-04 PET/CT 成像之前都进行了肾穿刺。然后，他们接受了 [Ga]Ga-FAPI-04 PET/CT 和免疫化学检查。对获得的数据进行了分析。
[Ga]Ga-FAPI-04 PET/CT 检查结果表明，几乎所有患者（12/13）的放射性示踪剂摄取均增加。轻度、中度和重度纤维化患者的最大标准化摄取值（SUVmax）分别为 3.92±1.50、5.98±1.6 和 7.67±2.23。
与肾穿刺检查相比，通过 [Ga]Ga-FAPI-04 PET/CT 对 FAP 表达进行无创成像可以快速、高敏感地显示双侧肾脏情况。[Ga]Ga-FAPI-04 PET/CT 有助于评估疾病进展、诊断和制定治疗方案。
