Aref Abdel-Baset M, Momenah Maha A, Jad Mariam M, Semmler Margit, Mohamedaiin Hoda S, Ahmed Ahmed, Mohamedien Dalia
Cell Biology and Histochemistry Division, Zoology Department, Faculty of Science, South Valley University, Qena, Egypt.
Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt.
Microsc Microanal. 2021 Apr 8:1-13. doi: 10.1017/S1431927621000271.
Tramadol is used worldwide and is listed in many medical guidelines to treat both acute and chronic pains. There is a growing evidence of abuse of tramadol in some African and West Asian countries. Tramadol has some side effects. The present study designed to follow up the treatment of the cellular responses which might be induced in the kidney of tramadol mice. Treated mice received daily injection of tramadol dose (125 μg/100 g b.wt) for 20 and 40 days. Other mice received tramadol for 40 days and then were divided into three groups: the first received distilled water, the second received Lagenaria siceraria, and the third received melatonin daily for 40 days. Both the daily injection of tramadol for 20 and 40 days resulted in radical, extensive, and severe alterations in the normal histological architecture of the kidney. Treatment with Lagenaria siceraria or melatonin after tramadol administration for a long-term, markedly changed the collagen content and other chemical components, that may reach nearly normal levels. Such findings propose that although tramadol has many cytological and histopathological side effects on the kidneys of male mice, the treatments via Lagenaria siceraria and melatonin have effective therapeutic impacts on the tramadol side effects.
曲马多在全球范围内被使用，并且在许多医学指南中被列为治疗急性和慢性疼痛的药物。在一些非洲和西亚国家，曲马多滥用的证据越来越多。曲马多有一些副作用。本研究旨在追踪曲马多处理小鼠肾脏中可能诱导的细胞反应的治疗情况。处理过的小鼠每天注射曲马多剂量（125μg/100g体重），持续20天和40天。其他小鼠接受曲马多治疗40天，然后分为三组：第一组接受蒸馏水，第二组接受瓠瓜，第三组每天接受褪黑素，持续40天。每天注射曲马多20天和40天均导致肾脏正常组织结构发生根本性、广泛性和严重性改变。长期给予曲马多后用瓠瓜或褪黑素治疗，明显改变了胶原蛋白含量和其他化学成分，这些成分可能接近正常水平。这些发现表明，尽管曲马多对雄性小鼠肾脏有许多细胞学和组织病理学副作用，但通过瓠瓜和褪黑素进行的治疗对曲马多的副作用有有效的治疗作用。
