Dr Saima Haque Lisa, Assistant Professor, Department of Physiology, Parkview Medical College, Sylhet, Bangladesh; E-mail:
Mymensingh Med J. 2021 Apr;30(2):473-477.
Preeclampsia is a multifactorial disease of unknown etiology and is associated with oxidative stress. Some studies observed that alteration of essential trace element may contribute to the development of preeclampsia. The aim of the study was to assess the serum copper (Cu) level and its relation with blood pressure and urinary protein level in preeclampsia. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from July 2016 to June 2017. Thirty subjects with preeclampsia age ranging from 18 to 40 years were considered as the study group and 30 aged matched healthy pregnant women were considered as control group for comparison. The subjects were selected from Department of Obstetrics and Gynecology of Dhaka Medical College hospital, Dhaka. Serum copper (Cu) level was estimated in the Department of Soil, Water and Environment of University of Dhaka. For statistical analysis, unpaired Students "t" test and Pearson's correlation coefficient (r) test were performed. In this study serum Copper level was significantly (p<0.001) higher in preeclampsia patients as compared to controls. Serum copper level showed positive correlations with systolic & diastolic blood pressure and urinary protein level. This study concluded that serum copper level increases and is positively related with blood pressure and urinary protein level. Therefore, estimation of serum copper level in early pregnancy might be useful for prediction of future risk of developing preeclampsia.
子痫前期是一种病因不明的多因素疾病，与氧化应激有关。一些研究观察到，必需微量元素的改变可能导致子痫前期的发生。本研究旨在评估子痫前期患者血清铜（Cu）水平及其与血压和尿蛋白水平的关系。本横断面研究于 2016 年 7 月至 2017 年 6 月在孟加拉国达卡医学院生理学系进行。将 30 名年龄在 18 至 40 岁的子痫前期患者视为研究组，30 名年龄匹配的健康孕妇视为对照组进行比较。这些受试者均选自达卡医学院附属医院妇产科。血清铜（Cu）水平在达卡大学土壤、水和环境系进行评估。采用非配对学生 t 检验和 Pearson 相关系数（r）检验进行统计分析。本研究结果表明，与对照组相比，子痫前期患者血清铜（Cu）水平显著升高（p<0.001）。血清铜水平与收缩压和舒张压以及尿蛋白水平呈正相关。本研究得出结论，血清铜水平升高与血压和尿蛋白水平呈正相关。因此，在早期妊娠时测定血清铜水平可能有助于预测未来发生子痫前期的风险。
