Dr Fayeza Karim, Associate Professor & Head, Department of Physiology, East West Medical College, Dhaka, Bangladesh; E-mail:
Mymensingh Med J. 2022 Apr;31(2):395-399.
The patient with diabetes mellitus (DM) and its complication is increasing in our country and all over the world. Fibrinogen is a renowned factor of progressive atherosclerotic lesions and a predictor of cardiovascular events. Level of fibrinogen is increases in patients with diabetes mellitus (DM) may accelerate thromboembolic risk for cardiovascular disease (CVD). This study was carried out to assess plasma fibrinogen level in subjects with type 2 diabetes mellitus. It was a cross sectional analytic study and conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from July 2013 to June 2014. A total number of 200 adult male subjects were selected with age ranging from 40-60 years. Among them, 100 subjects with type 2 diabetes mellitus were included in the study group (Group B) and 100 healthy subjects with same age range were considered as controls (Group A) for comparison. The subjects were selected from BIRDEM hospital Dhaka and personal contact from different areas of Dhaka city on the basis of exclusion and inclusion criteria. The study parameter was plasma fibrinogen level, and was measured in the Department of Microbiology and Immunology of BIRDEM hospital, Dhaka, Bangladesh. The data were collected and recorded in pre-designed structured questionnaire by the researcher herself. For statistical analyses unpaired Student's 't' test and Pearson's correlation coefficient (r) test were performed as applicable using SPSS for windows version 19.0. In this study plasma fibrinogen level was significantly (p<0.001) higher in the study group than that of control group. From this study, it may be concluded that estimation of plasma fibrinogen level might be beneficial for prediction of future cardiovascular risk in adult diabetic male.
我国乃至全世界的糖尿病（DM）及其并发症患者都在不断增加。纤维蛋白原是公认的进行性动脉粥样硬化病变的因素，也是心血管事件的预测因子。糖尿病（DM）患者纤维蛋白原水平升高可能会加速心血管疾病（CVD）的血栓栓塞风险。本研究旨在评估 2 型糖尿病患者的血浆纤维蛋白原水平。这是一项横断面分析研究，于 2013 年 7 月至 2014 年 6 月在孟加拉国达卡医学院生理学系进行。共选择了 200 名年龄在 40-60 岁之间的成年男性受试者。其中，100 名 2 型糖尿病患者纳入研究组（B 组），100 名年龄相同的健康受试者作为对照组（A 组）进行比较。研究对象从达卡的 BIRDEM 医院选择，并根据排除和纳入标准从达卡市的不同地区进行个人联系。研究参数为血浆纤维蛋白原水平，在孟加拉国达卡的 BIRDEM 医院的微生物学和免疫学系进行测量。数据由研究人员本人使用预设计的结构化问卷收集和记录。对于统计分析，使用 SPSS for windows 版本 19.0 进行了非配对学生 t 检验和 Pearson 相关系数（r）检验。在这项研究中，研究组的血浆纤维蛋白原水平明显（p<0.001）高于对照组。从这项研究中可以得出结论，估计血浆纤维蛋白原水平可能有助于预测成年男性糖尿病患者未来的心血管风险。
