Branković-Magić M, Nikolić-Vukosavljević D, Nesković-Konstantinović Z, Kanjer K, Spuzić I
Institute of Oncology and Radiology, Belgrade, Yugoslavia.
Pathol Res Pract. 1995 Feb;191(1):16-24. doi: 10.1016/S0344-0338(11)80917-9.
Estrogen and progesterone receptor content was determined in 34 patients with synchronous and 23 patients with asynchronous bilateral breast cancer. Steroid receptor content was measured quantitatively by DCC method. It was shown that progesterone receptor content could not be predicted, as well as, that steroid receptor content of the second tumor significantly influenced the development of asynchronous bilateral breast cancer. The high discordance rate concerning histologic type between two tumors within synchronous as well as asynchronous biopsies was observed. The obtained results indicate that both synchronous and asynchronous bilateral breast tumors may be considered as biologically different tumors whose both steroid receptor levels should be determined whenever possible.
对34例同步性双侧乳腺癌患者和23例非同步性双侧乳腺癌患者的雌激素和孕激素受体含量进行了测定。采用葡聚糖包被活性炭法（DCC法）对类固醇受体含量进行定量测定。结果表明，孕激素受体含量无法预测，而且，第二个肿瘤的类固醇受体含量对非同步性双侧乳腺癌的发展有显著影响。在同步及非同步活检中，观察到两个肿瘤之间组织学类型的高不一致率。所得结果表明，同步性和非同步性双侧乳腺肿瘤都可被视为生物学上不同的肿瘤，只要有可能，都应测定其类固醇受体水平。
