Department of Health Science, Graduate School at Korea University, Seoul, Republic of Korea.
Asbestos Environmental Health Center, Soonchunhyang University Cheonan Hospital, Cheonan-si, Chungcheongnam-do, Republic of Korea.
PLoS One. 2021 Apr 8;16(4):e0249790. doi: 10.1371/journal.pone.0249790. eCollection 2021.
Despite the use of large amounts of asbestos in the 1990s, few studies have been conducted in Korea on occupational and environmental asbestos exposure and lung cancer risk. The main aim of this study was to estimate the risk of lung cancer development caused by occupational and environmental asbestos exposures in residents of South Chungcheong Province, where about half of the asbestos mines in Korea operated. We conducted a case-control study, for which the information on asbestos exposure history and demographic characteristics was provided by the Environmental Health Center for asbestos of Soonchunhyang University Cheonan Hospital. After adjusting for all covariates, the odds ratios for lung cancer tended to increase with higher exposure probability for both occupational as well as environmental asbestos. The relative risk of occupational asbestos exposure was higher than that of environmental exposure; the interaction of co-exposure was not statistically significant. The estimated means of the latency period were significantly shorter in participants who were engaged in the production of asbestos-containing products and in those who lived near asbestos industries as compared to other groups.
尽管 20 世纪 90 年代大量使用了石棉，但韩国几乎没有开展关于职业和环境石棉暴露与肺癌风险的研究。本研究的主要目的是评估在韩国约一半石棉矿运营的忠清南道居民中，因职业和环境石棉暴露而导致肺癌发展的风险。我们进行了一项病例对照研究，石棉暴露史和人口统计学特征的信息由顺天乡大学天安医院的环境健康中心提供。在调整了所有协变量后，肺癌的比值比倾向于随着职业和环境石棉暴露概率的增加而增加。职业石棉暴露的相对风险高于环境暴露；共同暴露的交互作用无统计学意义。与其他组相比，从事含石棉产品生产的参与者和居住在石棉工业附近的参与者的潜伏期估计平均值明显较短。
