Black W C
University of New Mexico School of Medicine, Department of Pathology, Albuquerque.
Cancer. 1988 Jul 1;62(1):163-73. doi: 10.1002/1097-0142(19880701)62:1<163::aid-cncr2820620126>3.0.co;2-n.
Excision biopsies of 500 invasive superficial spreading melanomas were examined for evidence of residual melanocytic dysplasia (remnants of dysplastic nevi). Melanocytic dysplasia was identified in 32.4% of tumors. Remnants of nevi without melanocytic dysplasia were found in 9.8%. Sun damage as evidenced by solar elastosis was histologically estimated in contiguous skin. Patients' age at diagnosis, tumor site, pathologic stage, evidence of tumor regression, and coexisting sun damage were correlated with the presence or absence of melanocytic dysplasia. Patients whose tumors displayed residual dysplasia were younger and demonstrated a more favorable tumor stage and less evidence of sun damage. Melanomas on the trunk were more likely to be associated with melanocytic dysplasia than those from other areas. The findings support the belief that dysplastic nevi have an important role in the genesis of superficial spreading melanoma. The influence of ultraviolet radiation in the development of dysplastic nevi and in their potential malignant progression is discussed.
对500例浸润性浅表扩散性黑色素瘤的切除活检标本进行检查，以寻找残余黑素细胞发育异常（发育异常痣的残余）的证据。在32.4%的肿瘤中发现了黑素细胞发育异常。在9.8%的病例中发现了无黑素细胞发育异常的痣残余。通过组织学评估相邻皮肤中日光性弹力组织变性所证明的阳光损伤情况。将患者的诊断年龄、肿瘤部位、病理分期、肿瘤消退证据以及并存的阳光损伤与黑素细胞发育异常的有无进行关联分析。肿瘤显示有残余发育异常的患者更年轻，肿瘤分期更有利，阳光损伤证据更少。躯干上的黑色素瘤比其他部位的黑色素瘤更有可能与黑素细胞发育异常相关。这些发现支持了发育异常痣在浅表扩散性黑色素瘤发生中起重要作用的观点。文中还讨论了紫外线辐射在发育异常痣发生及其潜在恶性进展中的影响。
