• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

重新审视帕金森病中的多巴胺-乙酰胆碱失衡：谷氨酸共传递作为一个令人兴奋的犯罪伙伴。

Revisiting dopamine-acetylcholine imbalance in Parkinson's disease: Glutamate co-transmission as an exciting partner in crime.

机构信息

Department of Physiology, Anatomy and Genetics, and Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3PT, UK.

Department of Physiology, Anatomy and Genetics, and Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3PT, UK.

出版信息

Neuron. 2021 Apr 7;109(7):1070-1071. doi: 10.1016/j.neuron.2021.03.018.

DOI:10.1016/j.neuron.2021.03.018
PMID:33831360
Abstract

Striatal dopamine and acetylcholine are thought to be imbalanced in Parkinson's disease. In this issue of Neuron, Cai et al. report that restoration of nigral glutamate co-transmission, acting on dorsolateral striatal cholinergic interneuron mGluR1s, can rescue motor dysfunction in a mouse model of Parkinson's.

摘要

纹状体中的多巴胺和乙酰胆碱被认为在帕金森病中失衡。在本期《神经元》杂志中，Cai 等人报告称，恢复黑质谷氨酸共传递，作用于背外侧纹状体胆碱能中间神经元的 mGluR1s，可以挽救帕金森病小鼠模型的运动功能障碍。

相似文献

1
Revisiting dopamine-acetylcholine imbalance in Parkinson's disease: Glutamate co-transmission as an exciting partner in crime.重新审视帕金森病中的多巴胺-乙酰胆碱失衡：谷氨酸共传递作为一个令人兴奋的犯罪伙伴。
Neuron. 2021 Apr 7;109(7):1070-1071. doi: 10.1016/j.neuron.2021.03.018.
2
Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments.黑质中胆碱能中间神经元的兴奋缺失导致帕金森病运动障碍。
Neuron. 2021 Apr 7;109(7):1137-1149.e5. doi: 10.1016/j.neuron.2021.01.028. Epub 2021 Feb 17.
3
Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease.胆碱能中间神经元对帕金森病纹状体病理生理学的贡献。
Neurochem Int. 2019 Jun;126:1-10. doi: 10.1016/j.neuint.2019.02.019. Epub 2019 Feb 27.
4
Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate.多巴胺细胞通过多巴胺和谷氨酸的共释放差异调节纹状体胆碱能传递跨越区域。
Cell Rep. 2018 Dec 11;25(11):3148-3157.e3. doi: 10.1016/j.celrep.2018.11.053.
5
Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models.胆碱能中间神经元放大帕金森病模型中丘脑纹状体兴奋对纹状体间接通路神经元的兴奋。
Neuron. 2019 Feb 6;101(3):444-458.e6. doi: 10.1016/j.neuron.2018.12.004. Epub 2019 Jan 15.
6
Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors.靶向帕金森病中的纹状体胆碱能中间神经元：聚焦于代谢型谷氨酸受体
Neuropharmacology. 2003 Jul;45(1):45-56. doi: 10.1016/s0028-3908(03)00137-0.
7
Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease.纹状体胆碱能中间神经元以及M1和M4毒蕈碱受体在帕金森病运动症状中的作用
J Neurosci. 2016 Aug 31;36(35):9161-72. doi: 10.1523/JNEUROSCI.0873-16.2016.
8
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.帕金森病中胆碱能和 GABA 能纹状体中间神经元的 GABA 能抑制作用被消除。
Nat Commun. 2018 Apr 12;9(1):1422. doi: 10.1038/s41467-018-03802-y.
9
Cholinergic/glutamatergic co-transmission in striatal cholinergic interneurons: new mechanisms regulating striatal computation.纹状体胆碱能中间神经元中的胆碱能/谷氨酸能共同传递：调节纹状体计算的新机制。
J Neurochem. 2017 Aug;142 Suppl 2:90-102. doi: 10.1111/jnc.14003. Epub 2017 Apr 18.
10
Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons.纹状体胆碱能中间神经元释放的乙酰胆碱和谷氨酸的行为效应的功能分离。
FASEB J. 2022 Feb;36(2):e22135. doi: 10.1096/fj.202101425R.

引用本文的文献

1
Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments.症状前帕金森病的血液检测：对转运RNA片段中的重复序列基序进行定量分析
Nat Aging. 2025 May;5(5):868-882. doi: 10.1038/s43587-025-00851-z. Epub 2025 Apr 11.
2
Effects of Chronic Exposure to Low Doses of Rotenone on Dopaminergic and Cholinergic Neurons in the CNS of .鱼藤酮慢性低剂量染毒对. 中枢神经系统多巴胺能和胆碱能神经元的影响。
Int J Mol Sci. 2024 Jun 28;25(13):7159. doi: 10.3390/ijms25137159.
3
The Construction and Validation of a Novel Ferroptosis-Related Gene Signature in Parkinson's Disease.
构建并验证帕金森病中新型铁死亡相关基因特征。
Int J Mol Sci. 2023 Dec 6;24(24):17203. doi: 10.3390/ijms242417203.
4
Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities.线粒体与脑部疾病：病理机制与治疗机遇的全面综述
Biomedicines. 2023 Sep 7;11(9):2488. doi: 10.3390/biomedicines11092488.