Clemente-Suárez Vicente Javier, Redondo-Flórez Laura, Beltrán-Velasco Ana Isabel, Ramos-Campo Domingo Jesús, Belinchón-deMiguel Pedro, Martinez-Guardado Ismael, Dalamitros Athanasios A, Yáñez-Sepúlveda Rodrigo, Martín-Rodríguez Alexandra, Tornero-Aguilera José Francisco
Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain.
Group de Investigación en Cultura, Educación y Sociedad, Universidad de la Costa, Barranquilla 080002, Colombia.
Biomedicines. 2023 Sep 7;11(9):2488. doi: 10.3390/biomedicines11092488.
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions.
线粒体在维持细胞能量稳态、调节细胞凋亡以及控制氧化还原信号传导方面发挥着至关重要的作用。线粒体功能障碍与包括神经退行性疾病、中风和精神疾病在内的各种脑部疾病的发病机制有关。这篇综述文章全面概述了线粒体与脑部疾病之间的复杂关系，重点关注潜在的病理机制并探索潜在的治疗机会。该综述涵盖了关键主题，如脑部疾病背景下的线粒体DNA突变、氧化磷酸化受损、线粒体动力学、钙调节异常以及活性氧生成。此外，它还讨论了针对线粒体功能障碍的新兴策略，包括线粒体保护剂、代谢调节剂和基因治疗方法。通过批判性地分析现有文献和最新进展，本综述旨在加深我们对线粒体在脑部疾病中多方面作用的理解，并为新的治疗干预措施提供启示。
