Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine.
School of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Medicine (Baltimore). 2021 Apr 9;100(14):e25355. doi: 10.1097/MD.0000000000025355.
Ulcerative colitis (UC) is a kind of chronic non-specific ulcerative colitis, which is characterized by repeated abdominal pain, diarrhea, and mucus purulent stool. The disease is more recurrent, easy to delay, and canceration, seriously affect the quality of life, increase the economic burden of patients and society, treatment is more difficult, the World Health Organization as one of the modern refractory diseases. Shenling Atractylodes Powder in the treatment of ulcerative colitis showed a strong advantage, the effect is accurate. Therefore, this paper will systematically evaluate and meta-analyze the efficacy and safety of heat-sensitive moxibustion in the treatment of ulcerative colitis.
Eight electronic databases were searched, including the PubMed, Embase, Web of Science, Cochrane Library, China National knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and China Biomedical Literature Database. We will search in the above electronic database from early 2021 to December without any language restrictions. Outcome indicators, including colonic mucosal symptom score Mayo colonoscopy grading, total effective rate, total incidence of adverse reactions, clinical symptom score, recurrence rate, laboratory indicators: IL-6, IL-9, TNF-α, IL-4, IL-10 inflammation-related factor levels. Rev Man5.3 software will be used for statistical analysis. The efficacy and safety results of Shenling Atractylodes Powder in the treatment of ulcerative colitis will be used as the average difference between the risk ratio of dichotomy data and the 95% co-card interval of continuous data.
When this research program is completed, the relevant results can be obtained.
This article does not need to pass the ethics committee review, because this article does not involve the ethics question, only collates the related literature research. The results of this study will be disseminated in the form of a paper to help better guide the clinical practice of heat-sensitive moxibustion in the treatment of ulcerative colitis.
INPLASY202120018.
溃疡性结肠炎（UC）是一种慢性非特异性溃疡性结肠炎，其特征为反复腹痛、腹泻和黏液脓性粪便。该疾病更易复发、迁延难愈、癌变，严重影响生活质量，增加患者和社会的经济负担，治疗更为困难，世界卫生组织将其列为现代难治性疾病之一。升阳益胃汤在溃疡性结肠炎的治疗中显示出较强优势，疗效确切。因此，本研究将系统评价和 Meta 分析热敏灸治疗溃疡性结肠炎的疗效和安全性。
检索 PubMed、Embase、Web of Science、Cochrane Library、中国知网、中国科技期刊数据库、万方数据库、中国生物医学文献数据库 8 个电子数据库，检索时间为 2021 年 1 月至 2021 年 12 月，无语言限制。结局指标包括结肠黏膜症状评分 Mayo 结肠镜分级、总有效率、不良反应总发生率、临床症状评分、复发率、实验室指标：IL-6、IL-9、TNF-α、IL-4、IL-10 炎症相关因子水平。采用 Rev Man5.3 软件进行统计学分析。升阳益胃汤治疗溃疡性结肠炎的疗效及安全性结果，以二分类资料的风险比及其 95%置信区间、连续性资料的均数差值表示。
当完成此研究方案时，将获得相关结果。
本文不需要通过伦理委员会审查，因为本文不涉及伦理问题，仅整理相关文献研究。本研究结果将以论文形式发表，以帮助更好地指导热敏灸治疗溃疡性结肠炎的临床实践。
INPLASY202120018。
