College of clinical medicine, Jiangxi University of Traditional Chinese Medicine.
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Medicine (Baltimore). 2021 Jan 29;100(4):e24078. doi: 10.1097/MD.0000000000024078.
Ulcerative colitis (UC) is a chronic nonspecific intestinal inflammatory disease with unclear etiology occurring in the colonic mucosa. Its clinical manifestations are characterized by recurrent abdominal pain, diarrhea, mucous pus, and blood stool. The severity of the disease varies, and itis characterized by a high recurrence rate. Because of its long course of disease, easy to relapse, protracted and difficult to recover, seriously affect the quality of life, increase the economic burden of patients and society, and even the risk of developing cancer, it has become one of the hot issues of general concern in the medical field. Heat-sensitive moxibustion therapy has shown strong advantages in the treatment of UC, and the curative effect is accurate. therefore, this paper will carry out a systematic evaluation and meta analysis of the efficacy and safety of heat-sensitive moxibustion in the treatment of UC.
We will be searching 8 electronic databases, including PubMed, Embase, Web of Science, Cochrane Library, the China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wanfang Database, and Chinese Biomedical Literature Database. We will search above electronic databases from the beginning to December 2020, without any language restriction. Clinical efficacy, including total effective rate or cure rate, clinical symptom integral (abdominal pain, diarrhea, purulent stool), and recurrence rate will be accepted as the primary outcomes. The changes of cytokine Hs-CRP, IL-6, TNF-αlevels in serum, and improvement of colorectal mucosa will be used as secondary outcomes. RevMan 5.3 software will be used for statistical analysis. The result about the curative effect and safety of heat-sensitive moxibustion for UC will be presented as risk ratio for dichotomous data and mean differences with a 95% confidence interval for continuous data.
When this research program is completed, the relevant results can be obtained.
The results of this study will provide reliable evidence for the efficacy and safety of heat-sensitive moxibustion in the treatment of UC.
INPLASY20201101034.
溃疡性结肠炎（UC）是一种病因不明的慢性非特异性肠道炎症性疾病，发生在结肠黏膜。其临床表现为反复发作的腹痛、腹泻、黏液脓血便和血便。疾病的严重程度不同，其特点是复发率高。由于其病程长、易复发、迁延难愈，严重影响生活质量，增加了患者和社会的经济负担，甚至有发展为癌症的风险，已成为医学领域普遍关注的热点问题之一。热敏灸疗法在治疗 UC 方面表现出了强大的优势，疗效确切。因此，本研究将对热敏灸治疗 UC 的疗效和安全性进行系统评价和 Meta 分析。
我们将检索 8 个电子数据库，包括 PubMed、Embase、Web of Science、Cochrane 图书馆、中国知网、中国科技期刊数据库、万方数据库和中国生物医学文献数据库。我们将从开始检索到 2020 年 12 月，对以上电子数据库进行无语言限制的检索。临床疗效（包括总有效率或治愈率）、临床症状积分（腹痛、腹泻、脓血便）和复发率将作为主要结局。血清中细胞因子 Hs-CRP、IL-6、TNF-α水平的变化以及结直肠黏膜的改善将作为次要结局。采用 RevMan 5.3 软件进行统计学分析。热敏灸治疗 UC 的疗效和安全性的结果将以二分类数据的风险比和连续数据的均数差及其 95%置信区间表示。
当这个研究项目完成时，将得到相关结果。
本研究的结果将为热敏灸治疗 UC 的疗效和安全性提供可靠的证据。
INPLASY 注册号：INPLASY20201101034。
