Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Qihuang Outpatient Department of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Medicine (Baltimore). 2021 Apr 9;100(14):e25436. doi: 10.1097/MD.0000000000025436.
Hemifacial spasm (HFS) is a clinical common neurological disease, its main performance for 1 side or 2 sides muscles (the orbicularis oculi muscle, expression, orbicularisoris muscles) recurrent paroxysmal, involuntary twitching, aggravating when excited or nervous, more severe cases of the disease may include difficulty in opening the eyes, crooked corners of the mouth, and twitching noises in the ears, etc.[1] Early manifestations of the disease are intermittent mild convulsions of the orbicularis oculi muscle, and then gradually spread to 1 side of the facial muscles, such as frowning muscles, nasal muscles, buccinalis muscles, etc, especially the most obvious spasms of the oral muscles, which can involve the ipsilateral platysma muscle in severe cases, with each twitch for a few seconds to a few minutes. The disease will affect the quality of life such as speaking, eating, seeing and so on, and even cause psychological effects such as inferiority, anxiety and depression. At present, the incidence of the disease in China is 11 per 1.1 million, females are more common than males. There are many ways to treat HFS, but the Qianzheng powder has a unique advantage in treating this disease. Therefore, our systematic review aims to evaluate the efficacy and safety of Qianzheng powder in the treatment of Primary Hemifacial spasm, and to provide a reliable basis for clinical decision makers.
From its inception until April 2021, we will search electronic databases, including PubMed, Embase, Cochrane Library, China Biomedical Literature Database, China Knowledge Infrastructure, Wanfang Database, and China Scientific Journals Database. The authors will independently sift through studies, extract data information, and assess methodological quality using the Cochrane Risk of Bias tool. The RevManV. 5.3 software will be used for statistical analysis.
The results of this study, which will be published in a peerreviewed journal, will evaluate the efficacy and safety of Qianzheng powder in the treatment of primary Hemifacial spasm.
This systematic review will provide reliable evidence-based basis for treating primary Hemifacial spasm with Qianzheng powder.
INPLASY202130037.
面肌痉挛（HFS）是一种临床常见的神经系统疾病，其主要表现为单侧或双侧面部肌肉（眼轮匝肌、表情肌、口轮匝肌）反复发作、阵发性、不自主抽搐，兴奋或紧张时加重，病情严重者可出现睁眼困难、口角歪斜、耳内抽搐声等[1]。疾病早期表现为眼轮匝肌间歇性轻度抽搐，逐渐扩散至单侧面部肌肉，如皱眉肌、鼻肌、颊肌等，尤以口轮匝肌最明显抽搐，严重者可累及同侧颈阔肌，每次抽搐持续数秒至数分钟。疾病会影响说话、进食、视物等生活质量，甚至会导致自卑、焦虑、抑郁等心理影响。目前，我国该病发病率为 11/110 万，女性多于男性。HFS 有多种治疗方法，但牵正散在治疗该病方面具有独特优势。因此，我们的系统评价旨在评估牵正散治疗原发性面肌痉挛的疗效和安全性，为临床决策者提供可靠依据。
从成立到 2021 年 4 月，我们将检索电子数据库，包括 PubMed、Embase、Cochrane 图书馆、中国生物医学文献数据库、中国知网、万方数据库和中国科技期刊数据库。作者将独立筛选研究、提取数据信息，并使用 Cochrane 偏倚风险工具评估方法学质量。统计分析将使用 RevManV.5.3 软件。
本研究结果将发表在同行评议期刊上，评估牵正散治疗原发性面肌痉挛的疗效和安全性。
本系统评价将为牵正散治疗原发性面肌痉挛提供可靠的循证依据。
INPLASY 注册号：INPLASY202130037。
