Huang Lili, Gao Lin, Chen Chen
School of Biomedical Science and Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Australia.
School of Biomedical Science and Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Australia.
Trends Endocrinol Metab. 2021 Jun;32(6):351-366. doi: 10.1016/j.tem.2021.03.002. Epub 2021 Apr 5.
Medium-chain fatty acids (MCFAs) serve not only as an energy source but also regulate glucose and lipid metabolism. The unique transport and rapid metabolism of MCFAs provide additional clinical benefits over other substrates such as long-chain fatty acids (LCFAs) and have prompted interest in the use of MCFAs for treating metabolic and neurological disorders. This review focuses on the metabolic role of MCFAs in modulating cellular signaling and regulating key circulating metabolites and hormones. The potential of MCFAs in treating various metabolic diseases in a clinical setting has also been analyzed.
中链脂肪酸（MCFAs）不仅作为一种能量来源，还能调节葡萄糖和脂质代谢。与长链脂肪酸（LCFAs）等其他底物相比，MCFAs独特的转运和快速代谢具有额外的临床益处，并引发了人们对使用MCFAs治疗代谢和神经疾病的兴趣。本综述重点关注MCFAs在调节细胞信号传导以及调控关键循环代谢物和激素方面的代谢作用。还分析了MCFAs在临床环境中治疗各种代谢疾病的潜力。
