Yan Xianghui, Peng Ting, Zeng Zheling, Wang Pengbo, Gao Yifang, Wen Xuefang, Xia Jiaheng, Gong Deming, Yu Ping
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.
College of Food Science and Technology, Nanchang University, Nanchang 330031, China.
Foods. 2025 Jun 17;14(12):2116. doi: 10.3390/foods14122116.
Medium chain triglycerides (MCTs) are regarded as an important ingredient for functional foods and nutraceuticals. seed kernel oil (CCSKO) contains more than 95% medium chain fatty acids (MCFAs), which is a significantly higher level than palm kernel oil (62%) and coconut oil (55%). However, the safety assessment of CCSKO, as the only natural MCT oil rich in capric acid and lauric acid found so far in the world, has not been fully verified. The study aimed to investigate the 90-day sub-chronic oral toxicity and teratogenicity of CCSKO. In the sub-chronic oral toxicity study, no clinically significant adverse events occurred in male or female Sprague-Dawley (SD) rats with CCSKO daily administration for 13 weeks. Moreover, there were no dose-response relationships between CCSKO and body-weight gain, food intake and food utilization in male or female SD rats. No significant differences ( > 0.05) were found in the hematological properties or organ weights between the male and female SD rats. In the teratogenicity test, no toxicological signs were observed in either Wister pregnant rats or fetuses. The no-observed-adverse-effect level of CCSKO was determined to be more than 4 mL/kg body weight. These results suggested that CCSKO may be an excellent edible oil with high oral safety.
中链甘油三酯（MCTs）被视为功能性食品和营养保健品的重要成分。 种仁油（CCSKO）含有超过95%的中链脂肪酸（MCFAs），这一水平显著高于棕榈仁油（62%）和椰子油（55%）。然而，CCSKO作为目前世界上发现的唯一富含癸酸和月桂酸的天然MCT油，其安全性评估尚未得到充分验证。该研究旨在调查CCSKO的90天亚慢性经口毒性和致畸性。在亚慢性经口毒性研究中，对雄性和雌性Sprague-Dawley（SD）大鼠每日给予CCSKO，持续13周，未发生具有临床意义的不良事件。此外，在雄性或雌性SD大鼠中，CCSKO与体重增加、食物摄入量和食物利用率之间不存在剂量反应关系。雄性和雌性SD大鼠的血液学特性或器官重量之间未发现显著差异（>0.05）。在致畸性试验中，Wister怀孕大鼠或胎儿均未观察到毒理学迹象。CCSKO的未观察到不良反应水平被确定为超过4 mL/kg体重。这些结果表明，CCSKO可能是一种具有高口服安全性的优质食用油。
