Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
Sci Rep. 2021 Apr 8;11(1):7804. doi: 10.1038/s41598-021-87367-9.
Sulforaphane (SFN), a naturally-occurring isothiocyanate enriched in cabbage and broccoli, has been provided as food supplements to improve weight management and reduce lipid levels. However, its effects on serum lipid profiles are contradictory. In this review, a meta-analysis and systematic review of SFN on lipid reduction and weight control is assessed with mice and rats fed on high-fat diet. The effects of SFN supplementation were evaluated by weighted mean difference (WMD) in body weight (BW), liver weight (LW) and also by its effect on serum lipids. A random-effects model was applied to estimate the overall summary effect. SFN reduced BW (WMD: - 2.76 g, 95% CI: - 4.19, - 1.34) and LW (WMD: - 0.93 g, 95% CI: - 1.63, - 0.23) significantly in our ten trials. Its effects on serum total cholesterol (TC) (WMD: - 15.62 mg/dL, 95% CI: - 24.07, - 7.18), low-density lipoprotein cholesterol (LDL-C) (WMD: - 8.35 mg/dL, 95% CI: - 15.47, - 1.24) and triglyceride (TG) (WMD: - 40.85 mg/dL, 95% CI: - 67.46, - 14.24) were significant except for high-density lipoprotein cholesterol (HDL-C) component (WMD: 1.05 mg/dL, 95% CI: - 3.44, 5.54). However, species, disease model, duration, SFN dosage as well as route of administration did not explain the heterogeneity among studies. In summary, these findings provide new insights concerning preclinical strategies for treating diseases including obesity, diabetes, hypertension, non-alcoholic fatty liver disease as well as cardiovascular disease with SFN supplements.
萝卜硫素（SFN）是一种天然存在的异硫氰酸盐，富含于甘蓝和西兰花中，已作为膳食补充剂提供，以改善体重管理和降低血脂水平。然而，其对血清脂质谱的影响存在争议。在本综述中，对高脂肪饮食喂养的小鼠和大鼠进行了 SFN 降低血脂和控制体重的荟萃分析和系统评价。通过体重（BW）、肝重（LW）的加权均数差（WMD）以及 SFN 对血清脂质的影响来评估 SFN 补充的效果。应用随机效应模型估计总体综合效应。我们的十项试验表明，SFN 可显著降低 BW（WMD：-2.76 g，95%CI：-4.19，-1.34）和 LW（WMD：-0.93 g，95%CI：-1.63，-0.23）。SFN 对血清总胆固醇（TC）（WMD：-15.62 mg/dL，95%CI：-24.07，-7.18）、低密度脂蛋白胆固醇（LDL-C）（WMD：-8.35 mg/dL，95%CI：-15.47，-1.24）和三酰甘油（TG）（WMD：-40.85 mg/dL，95%CI：-67.46，-14.24）的作用显著，但高密度脂蛋白胆固醇（HDL-C）（WMD：1.05 mg/dL，95%CI：-3.44，5.54）除外。然而，种属、疾病模型、持续时间、SFN 剂量以及给药途径并不能解释研究之间的异质性。总之，这些发现为使用 SFN 补充剂治疗肥胖症、糖尿病、高血压、非酒精性脂肪性肝病以及心血管疾病等疾病的临床前策略提供了新的见解。
