Cheng Arthur H, Cheng Hai-Ying Mary
Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Front Neurosci. 2021 Mar 23;15:659974. doi: 10.3389/fnins.2021.659974. eCollection 2021.
The suprachiasmatic nucleus (SCN) of the hypothalamus is the central circadian clock of mammals. It is responsible for communicating temporal information to peripheral oscillators via humoral and endocrine signaling, ultimately controlling overt rhythms such as sleep-wake cycles, body temperature, and locomotor activity. Given the heterogeneity and complexity of the SCN, its genesis is tightly regulated by countless intrinsic and extrinsic factors. Here, we provide a brief overview of the development of the SCN, with special emphasis on the murine system.
下丘脑的视交叉上核（SCN）是哺乳动物的中枢昼夜节律时钟。它负责通过体液和内分泌信号将时间信息传递给外周振荡器，最终控制诸如睡眠-觉醒周期、体温和运动活动等明显的节律。鉴于SCN的异质性和复杂性，其发生受到无数内在和外在因素的严格调控。在这里，我们简要概述SCN的发育，特别强调小鼠系统。
