• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名儿科患者因聚乙二醇（爽舒宝）配制不当引发的致命并发症

Lethal Complication From Inappropriately Prepared Polyethylene Glycol (Golytely) in a Pediatric Patient.

作者信息

Skaff Chahdah, Alayed Tareq

机构信息

Pediatric Critical Care Medicine, Dr. Sulaiman AL Habib Medical Group, Riyadh, SAU.

Pediatric Critical Care Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, SAU.

出版信息

Cureus. 2021 Mar 5;13(3):e13713. doi: 10.7759/cureus.13713.

DOI:10.7759/cureus.13713
PMID:33833924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8019517/
Abstract

Polyethylene glycol with electrolytes (PEG-ELS, Golytely) is a widely used osmotic solution for colonic preparation in adults who are undergoing colonoscopy or colon surgeries. In pediatric patients, It is approved for the same indications and as a treatment for severe chronic constipation. PEG-ELS has an acceptable safety profile and minimal side effects. The most common adverse effects are nausea and abdominal cramps. Golytely is known to cause minimal electrolyte disturbances with no major sequelae. A few case reports have been published describing the effect of PEG-ELS on the electrolytes. In this report, we present a case of an inappropriate preparation of Golytely administered to a pediatric patient leading to severe electrolyte disturbances and death.

摘要

聚乙二醇电解质散（PEG - ELS，复方聚乙二醇电解质散）是一种广泛用于接受结肠镜检查或结肠手术的成人结肠准备的渗透性溶液。在儿科患者中，它被批准用于相同适应症，并作为严重慢性便秘的治疗方法。PEG - ELS具有可接受的安全性和最小的副作用。最常见的不良反应是恶心和腹部绞痛。已知复方聚乙二醇电解质散引起的电解质紊乱最小，无重大后遗症。已经发表了一些病例报告描述了PEG - ELS对电解质的影响。在本报告中，我们介绍了一例给儿科患者不恰当使用复方聚乙二醇电解质散导致严重电解质紊乱和死亡的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/8019517/a917c1fa18e0/cureus-0013-00000013713-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/8019517/559224a22755/cureus-0013-00000013713-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/8019517/42824a45a12d/cureus-0013-00000013713-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/8019517/a917c1fa18e0/cureus-0013-00000013713-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/8019517/559224a22755/cureus-0013-00000013713-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/8019517/42824a45a12d/cureus-0013-00000013713-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/8019517/a917c1fa18e0/cureus-0013-00000013713-i03.jpg

相似文献

1
Lethal Complication From Inappropriately Prepared Polyethylene Glycol (Golytely) in a Pediatric Patient.一名儿科患者因聚乙二醇（爽舒宝）配制不当引发的致命并发症
Cureus. 2021 Mar 5;13(3):e13713. doi: 10.7759/cureus.13713.
2
Administration of olive oil followed by a low volume of polyethylene glycol-electrolyte lavage solution improves patient satisfaction with right-side colonic cleansing over administration of the conventional volume of polyethylene glycol-electrolyte lavage solution for colonoscopy preparation.相较于使用常规剂量的聚乙二醇电解质灌洗液进行结肠镜检查准备，先给予橄榄油再给予少量聚乙二醇电解质灌洗液可提高患者对右侧结肠清洁的满意度。
Gastrointest Endosc. 2009 Sep;70(3):515-21. doi: 10.1016/j.gie.2009.01.002. Epub 2009 Jun 24.
3
Randomised clinical trial: Polyethylene glycol 3350 with sports drink vs. polyethylene glycol with electrolyte solution as purgatives for colonoscopy--the incidence of hyponatraemia.随机临床试验：含运动饮料的聚乙二醇 3350 与含电解质溶液的聚乙二醇作为结肠镜检查的泻药——低钠血症的发生率。
Aliment Pharmacol Ther. 2014 Sep;40(6):610-9. doi: 10.1111/apt.12884. Epub 2014 Jul 28.
4
Unintentional intravenous infusion of Golytely in a 4-year-old girl.一名4岁女孩意外静脉输注了聚乙二醇电解质散剂（Golytely）。
Ann Pharmacother. 2004 Jul-Aug;38(7-8):1183-5. doi: 10.1345/aph.1E046. Epub 2004 Jun 1.
5
Comparison of a new sulfate-free polyethylene glycol electrolyte lavage solution versus a standard solution for colonoscopy cleansing.一种新型无硫酸盐聚乙二醇电解质灌洗液与标准溶液用于结肠镜检查肠道清洁的比较。
Gastrointest Endosc. 1990 May-Jun;36(3):285-9. doi: 10.1016/s0016-5107(90)71025-5.
6
Aspiration pneumonia due to polyethylene glycol-electrolyte solution (Golytely) treated by bronchoalveolar lavage.经支气管肺泡灌洗治疗的聚乙二醇电解质溶液（复方聚乙二醇电解质散）所致吸入性肺炎
Respirology. 2008 Jan;13(1):152-4. doi: 10.1111/j.1440-1843.2007.01209.x.
7
Colonic lavage solution (polyethylene glycol electrolyte lavage solution) as a treatment for chronic constipation: a double-blind, placebo-controlled study.结肠灌洗溶液（聚乙二醇电解质灌洗溶液）治疗慢性便秘：一项双盲、安慰剂对照研究。
Am J Gastroenterol. 1990 Mar;85(3):261-5.
8
The effect of stimulant laxatives and polyethylene glycol-electrolyte lavage solution for colonoscopy preparation on serum electrolytes and hemodynamics.
J Clin Gastroenterol. 2001 Mar;32(3):238-9. doi: 10.1097/00004836-200103000-00013.
9
Cost-analysis model of colonoscopy preparation using split-dose reduced-volume oral sulfate solution (OSS) and polyethylene glycol with electrolytes solution (PEG-ELS).使用分剂量减量口服硫酸溶液（OSS）和聚乙二醇电解质溶液（PEG-ELS）进行结肠镜检查准备的成本分析模型。
J Med Econ. 2016;19(4):356-63. doi: 10.3111/13696998.2015.1125907. Epub 2015 Dec 21.
10
Effect of mosapride citrate hydrate on the colon cleansing action of polyethylene glycol electrolyte lavage solution (PEG-ELS) in guinea pigs.水合枸橼酸莫沙必利对豚鼠聚乙二醇电解质灌洗液（PEG - ELS）结肠清洁作用的影响。
J Pharmacol Sci. 2009 Aug;110(4):415-23. doi: 10.1254/jphs.08331fp. Epub 2009 Jul 14.

本文引用的文献

1
Possible GoLytely-Associated Cardiac Arrest: A Case Report and Literature Review.可能与 Golytely 相关的心脏骤停：病例报告及文献复习。
J Pharm Pract. 2020 Jun;33(3):364-367. doi: 10.1177/0897190019825965. Epub 2019 Feb 6.
2
Urticaria as a Rare Side Effect of Polyethylene Glycol-3350 in a Child: Case Report.荨麻疹作为聚乙二醇-3350在儿童中罕见的副作用：病例报告
Acta Clin Croat. 2018 Mar;57(1):187-189. doi: 10.20471/acc.2018.57.01.26.
3
Severe symptomatic hyponatremia associated with the use of polyethylene glycol-based bowel preparation.
与使用聚乙二醇肠道准备剂相关的严重症状性低钠血症。
Endocrinol Diabetes Metab Case Rep. 2017 Feb 23;2017. doi: 10.1530/EDM-16-0119. eCollection 2017.
4
Administering Polyethylene Glycol Electrolyte Solution Via a Nasogastric Tube: Pulmonary Complications.经鼻胃管给予聚乙二醇电解质溶液：肺部并发症
Am J Crit Care. 2017 Mar;26(2):e11-e17. doi: 10.4037/ajcc2017522.
5
Electrolyte changes after bowel preparation for colonoscopy: A randomized controlled multicenter trial.结肠镜检查肠道准备后的电解质变化：一项随机对照多中心试验。
World J Gastroenterol. 2015 Mar 14;21(10):3041-8. doi: 10.3748/wjg.v21.i10.3041.
6
Urticaria due to polyethylene glycol-3350 and electrolytes for oral solution in a patient with jejunal nodular lymphoid hyperplasia.一名空肠结节性淋巴组织增生患者因口服聚乙二醇-3350和电解质溶液引发荨麻疹。
Ann Gastroenterol. 2015 Jan-Mar;28(1):148-150.
7
Bowel preparation for pediatric colonoscopy: report of the NASPGHAN endoscopy and procedures committee.儿童结肠镜检查的肠道准备：NASPGHAN内镜检查与操作委员会报告
J Pediatr Gastroenterol Nutr. 2014 Sep;59(3):409-16. doi: 10.1097/MPG.0000000000000447.
8
Mechanism of action and toxicities of purgatives used for colonoscopy preparation.泻药用于结肠镜检查准备的作用机制和毒性。
Expert Opin Drug Metab Toxicol. 2011 Jan;7(1):89-101. doi: 10.1517/17425255.2011.542411.
9
Commonly used preparations for colonoscopy: efficacy, tolerability, and safety--a Canadian Association of Gastroenterology position paper.结肠镜检查常用制剂：疗效、耐受性及安全性——加拿大胃肠病学协会立场文件
Can J Gastroenterol. 2006 Nov;20(11):699-710. doi: 10.1155/2006/915368.
10
Unintentional intravenous infusion of Golytely in a 4-year-old girl.一名4岁女孩意外静脉输注了聚乙二醇电解质散剂（Golytely）。
Ann Pharmacother. 2004 Jul-Aug;38(7-8):1183-5. doi: 10.1345/aph.1E046. Epub 2004 Jun 1.