Department of Cardiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.
Department of Ophthalmology, Huashan Hospital, Fudan University.
J Vis Exp. 2023 Dec 1(202). doi: 10.3791/65918.
Despite improvements in reducing hunger in recent years, undernutrition remains a global public health problem. This study utilizes the swept-source optical coherence tomography (SS-OCT) technique to assess changes in retinal and choroidal thickness in underweight subjects. Ophthalmic examinations were conducted on all adults participating in this cross-sectional research. Depending on their body mass index (BMI), the participants were divided into two groups: the underweight group and the normal group. The study included the right eyes of the underweight adults and an equal number of age- and gender-matched normal-weight subjects. The retinal thickness showed no significant difference between the underweight and normal groups (P > 0.05 for all). In males, the retina of the center and inner ring in the underweight group was significantly thinner than that in the normal group, while no such results were found in females. The choroid in the underweight group was significantly thinner compared to that in the normal group (all P < 0.05). Being underweight may affect choroidal thickness in both males and females. In comparison with underweight females, underweight males may experience more retinal damage. These findings contribute to a better understanding of the pathogenesis underlying specific ocular diseases in malnourished individuals.
尽管近年来在减少饥饿方面取得了进展，但营养不足仍然是一个全球性的公共卫生问题。本研究利用扫频源光相干断层扫描（SS-OCT）技术评估了体重不足受试者的视网膜和脉络膜厚度变化。对参与这项横断面研究的所有成年人进行了眼科检查。根据他们的体重指数（BMI），参与者被分为两组：体重不足组和正常组。该研究包括体重不足成年人的右眼和数量相等的年龄和性别匹配的正常体重受试者的右眼。体重不足组和正常组之间的视网膜厚度没有显著差异（所有 P > 0.05）。在男性中，体重不足组的中心和内环视网膜明显比正常组薄，而女性则没有这种结果。与正常组相比，体重不足组的脉络膜明显变薄（所有 P < 0.05）。体重不足可能会影响男性和女性的脉络膜厚度。与体重不足的女性相比，体重不足的男性可能会经历更多的视网膜损伤。这些发现有助于更好地了解营养不良个体特定眼部疾病的发病机制。
