Department of Otorhinolaryngology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Biosci Rep. 2021 Apr 30;41(4). doi: 10.1042/BSR20210522.
The relationship between IL-4 rs2243250 polymorphism and the risk of allergic rhinitis is not clear at present. The present study aims to evaluate the exact association between IL-4 rs2243250 polymorphism and susceptibility to allergic rhinitis by a meta-analysis.
The studies about IL-4 rs2243250 polymorphism associated with susceptibility to allergic rhinitis were searched using PubMed, Excerpta Medica Database (EMBASE), Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and China Wanfang databases. The last search time was on March 1, 2021. Data analysis was performed using Stata 15.0 software.
Nine documents were enrolled, from which 1709 patients with allergic rhinitis were included. Among them, six genotype frequencies in the control group conformed to Hardy-Weinberg Equilibrium (HWE). The meta-analysis of all included studies showed significant heterogeneity of each gene model. After omitting the studies whose genotype frequency in the control group did not meet the requirements of HWE, no significant heterogeneity was found in each gene model. The meta-analysis results of the control group genotypes in line with the HWE showed statistically significant differences in the pooled odds ratio (OR) of allele model (T vs. C), recessive model (TT vs. TC+CC) and homozygous model (TT vs. CC), which were 1.19 (95%CI: 1.04-1.35), 1.28 (95%CI: 1.06-1.55) and 1.56 (95%CI: 1.13-2.17), respectively. No statistically significant difference was observed in dominant and heterozygous genetic models.
IL-4 rs2243250 single nucleotide polymorphism associated with susceptibility to allergic rhinitis, allele T and genotype TT could increase the risk of allergic rhinitis.
目前，白细胞介素 4(rs2243250) 多态性与变应性鼻炎风险之间的关系尚不清楚。本研究旨在通过荟萃分析评估白细胞介素 4(rs2243250) 多态性与变应性鼻炎易感性之间的确切关系。
使用 PubMed、Excerpta Medica Database(EMBASE)、Web of Science、Cochrane Library、中国知网(CNKI)和万方数据库检索白细胞介素 4(rs2243250) 多态性与变应性鼻炎易感性相关的研究。最后一次检索时间为 2021 年 3 月 1 日。使用 Stata 15.0 软件进行数据分析。
共纳入 9 篇文献，其中纳入 1709 例变应性鼻炎患者。其中，对照组 6 种基因型频率符合 Hardy-Weinberg 平衡(HWE)。所有纳入研究的荟萃分析显示，各基因模型存在显著异质性。剔除对照组基因型不符合 HWE 要求的研究后，各基因模型均无显著异质性。符合 HWE 的对照组基因型的荟萃分析结果显示，等位基因模型(T 对 C)、隐性模型(TT 对 TC+CC)和纯合模型(TT 对 CC)的合并优势比(OR)有统计学意义，分别为 1.19(95%CI：1.04-1.35)、1.28(95%CI：1.06-1.55)和 1.56(95%CI：1.13-2.17)。显性和杂合遗传模型无统计学差异。
白细胞介素 4(rs2243250) 单核苷酸多态性与变应性鼻炎易感性相关，等位基因 T 和基因型 TT 可增加变应性鼻炎的发病风险。
