Tehran University of Medical Sciences, Tehran, Iran.
Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, Santa Catarina, Brazil.
Adv Exp Med Biol. 2021;1305:257-272. doi: 10.1007/978-981-33-6044-0_14.
According to the neurotrophic hypothesis of major depressive disorder (MDD), impairment in growth factor signaling might be associated with the pathology of this illness. Current evidence demonstrates that impaired neuroplasticity induced by alterations of neurotrophic growth factors and related signaling pathways may be underlying to the pathophysiology of MDD. Brain-derived neurotrophic factor (BDNF) is the most studied neurotrophic factor involved in the neurobiology of MDD. Nevertheless, developing evidence has implicated other neurotrophic factors, including neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), glial cell-derived neurotrophic factor (GDNF), and fibroblast growth factor (FGF) in the MDD pathophysiology. Here, we summarize the current literature on the involvement of neurotrophic factors and related signaling pathways in the pathophysiology of MDD.
根据重度抑郁症（MDD）的神经营养假说，生长因子信号的损伤可能与该疾病的病理学有关。目前的证据表明，神经营养因子和相关信号通路的改变引起的神经可塑性受损可能是 MDD 病理生理学的基础。脑源性神经营养因子（BDNF）是研究最多的与 MDD 神经生物学有关的神经营养因子。然而，越来越多的证据表明，其他神经营养因子，包括神经生长因子-3（NT-3）、神经生长因子-4（NT-4）、神经生长因子（NGF）、血管内皮生长因子（VEGF）、胰岛素样生长因子（IGF）、胶质细胞源性神经营养因子（GDNF）和纤维母细胞生长因子（FGF）也与 MDD 的病理生理学有关。在这里，我们总结了目前关于神经营养因子及相关信号通路在 MDD 病理生理学中作用的文献。
