Grieco C, Silipo C, Vittoria A
Farmaco Sci. 1977 Dec;32(12):909-22.
The antibacterial activity of a set of 1,5-benzodiazepine derivatives against Staph, aureus and Strep, pyogenes has been correlated with structural features of the compounds examined. It is shown by means of substituent constants and regression analysis that the lipophilic character of the molecule is the most important factor in determining its activity. Electronic and steric effects appear to be quite important.
一组1,5-苯二氮䓬衍生物对金黄色葡萄球菌和化脓性链球菌的抗菌活性已与所研究化合物的结构特征相关联。通过取代基常数和回归分析表明，分子的亲脂性是决定其活性的最重要因素。电子效应和空间效应似乎也相当重要。
