[补体级联反应在重症新型冠状病毒肺炎中的作用]
[Involvement of the complement cascade in severe forms of COVID-19].
作者信息
Chouaki Benmansour Nassima, Carvelli Julien, Vivier Éric
机构信息
Assistance Publique des Hôpitaux de Marseille, 80 rue Brochier, 13005 Marseille, France - Département universitaire de médecine générale, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France - Institut Paoli Calmettes, 232 boulevard de Sainte-Marguerite, 13009 Marseille, France.
Assistance Publique des Hôpitaux de Marseille, Hôpital de la Timone, Réanimation des urgences, 264 rue Saint-Pierre, 13005 Marseille, France - Aix-Marseille Université, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
出版信息
Med Sci (Paris). 2021 Apr;37(4):333-341. doi: 10.1051/medsci/2021021. Epub 2021 Apr 9.
The complement system is an essential component of the innate immune system. Its excessive activation during COVID-19 contributes to cytokine storm, disease-specific endothelial inflammation (endotheliitis) and thrombosis that comes with the disease. Targeted therapies of complement inhibition in COVID-19, in particular blocking the C5a-C5aR1 axis have to be taken into account in the establishment of potential biomarkers and development of therapeutic strategies in the most severe forms of the disease.
补体系统是固有免疫系统的重要组成部分。在新型冠状病毒肺炎（COVID-19）期间其过度激活会导致细胞因子风暴、疾病特异性内皮炎症（内皮炎）以及该疾病所伴随的血栓形成。在最严重形式的该疾病中，建立潜在生物标志物和制定治疗策略时必须考虑针对COVID-19的补体抑制靶向疗法，尤其是阻断C5a-C5aR1轴。
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