PARP14 与严重急性呼吸综合征冠状病毒 2 感染（COVID-19）之间的潜在关联。
The potential association between PARP14 and SARS-CoV-2 infection (COVID-19).
机构信息
Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Queensland 4229, Australia.
出版信息
Future Med Chem. 2021 Mar;13(6):587-592. doi: 10.4155/fmc-2020-0226. Epub 2021 Jan 20.
Understanding the potential association between the poly (ADP-ribose) polymerase member 14 (PARP14) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may aid in understanding the host immunopathological response to the virus. PARP14 has an emerging role in viral infections, and this article considers its potential mechanisms for action in either a pro- or anti-viral manner. It is evident that more experimental work is required; however, PARP14 appears vital in controlling the interferon response to the SARS-CoV-2 infection and has potential roles in balancing the proinflammatory cytokines of the cytokine storm. Furthermore, the SARS-CoV-2 macrodomain can prevent the PARP14-mediated antiviral response, suggesting a more complex relationship between PARP14 activity and SARS-CoV-2 infections.
了解多聚（ADP-核糖）聚合酶成员 14（PARP14）与严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）之间的潜在关联可能有助于了解宿主对病毒的免疫病理反应。PARP14 在病毒感染中具有新兴作用，本文考虑了其以促进或抗病毒方式发挥作用的潜在机制。显然，需要进行更多的实验工作；然而，PARP14 似乎对控制 SARS-CoV-2 感染的干扰素反应至关重要，并可能在平衡细胞因子风暴中的促炎细胞因子方面发挥作用。此外，SARS-CoV-2 的宏结构域可以阻止 PARP14 介导的抗病毒反应，这表明 PARP14 活性与 SARS-CoV-2 感染之间存在更复杂的关系。
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