Department of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH.
Medical Scientist Training Program, Case Western Reserve University, Cleveland, OH.
J Exp Med. 2021 May 3;218(5). doi: 10.1084/jem.20210273.
AIM2 is widely known for its role as a cytosolic dsDNA receptor that activates the inflammasome. In this issue of JEM, Ma et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201796) describe an inflammasome-independent function of AIM2 in microglia that restrains neuroinflammation via a novel crosstalk between AIM2 and cGAS signaling.
AIM2 作为胞质双链 DNA 受体，其激活炎症小体的作用广为人知。在本期《实验医学杂志》上，Ma 等人（2021. J. Exp. Med. https://doi.org/10.1084/jem.20201796）描述了 AIM2 在小胶质细胞中的一种炎症小体非依赖性功能，该功能通过 AIM2 和 cGAS 信号之间的新串扰来抑制神经炎症。
