受阻而非遗忘：细菌外毒素抑制翻译以激活 NLRP1。

Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1.

机构信息

Department of Microbiology, University of Washington, Seattle, WA, USA.

Molecular and Cellular Biology Graduate Program, University of Washington , Seattle, WA, USA.

出版信息

J Exp Med. 2023 Oct 2;220(10). doi: 10.1084/jem.20231160. Epub 2023 Aug 29.

DOI:10.1084/jem.20231160

PMID:37642998

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10465322/

Abstract

In this issue of JEM, companion articles from Pinilla et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230104) and Robinson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230105) demonstrate that ribotoxic stress induced by Pseudomonas aeruginosa and Corynebacterium diphtheriae EEF2-targeting exotoxins leads to NLRP1 inflammasome activation, representing a new mechanism of effector-triggered immunity.

摘要

在本期《实验医学杂志》中，Pinilla 等人的相关文章（2023. J. Exp. Med. https://doi.org/10.1084/jem.20230104）和 Robinson 等人的文章（2023. J. Exp. Med. https://doi.org/10.1084/jem.20230105）表明，铜绿假单胞菌和白喉棒状杆菌靶向真核延伸因子 2 的外毒素引起的核糖体毒性应激会导致 NLRP1 炎性体激活，这代表了效应触发免疫的一种新机制。