College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju Daero, Jinju, Gyeongnam, 52828, Republic of Korea.
College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, 197 Injero, Gimhae, Gyeongnam, 50834, Republic of Korea.
Pharm Res. 2021 May;38(5):873-883. doi: 10.1007/s11095-021-03038-4. Epub 2021 Apr 9.
To develop a hydrogel film containing bovine serum albumin (BSA)-coated silver nanoparticles (BSA/AgNP) and evaluate its applicability for topical photothermal treatment (PTT) of skin cancer.
BSA/AgNP-loaded hydrogel films were prepared and their swelling, bioadhesive, mechanical, and photothermal properties were characterized in vitro and in vivo.
The synthesized BSA/AgNP exhibited a narrow size distribution with good size stability and, notably, possessed great photothermal activity that could stably maintain through repetitive laser irradiation. The BSA/AgNP-loaded hydrogel films showed favorable swelling, bioadhesive, tensile, and photothermal properties. Based on these results, when tested the anti-cancer effects in B16F10 s.c. tumor-bearing mice, the PTT with the topical treatment of BSA/AgNP-loaded hydrogel films could significantly inhibit the tumor growth by a single treatment with no apparent toxicity.
Overall, the results of this study demonstrated that the BSA/AgNP-loaded hydrogel films may serve as an effective but safe topical PTT agent for the treatment of skin cancer.
开发一种含有牛血清白蛋白（BSA）包裹的银纳米粒子（BSA/AgNP）的水凝胶薄膜，并评估其在皮肤癌局部光热治疗（PTT）中的适用性。
制备 BSA/AgNP 负载的水凝胶薄膜，并对其体外和体内的溶胀、生物黏附、力学和光热性能进行了表征。
合成的 BSA/AgNP 具有较窄的粒径分布，粒径稳定性良好，具有显著的光热活性，可通过重复激光照射稳定维持。负载 BSA/AgNP 的水凝胶薄膜具有良好的溶胀、生物黏附、拉伸和光热性能。基于这些结果，在 B16F10 皮下荷瘤小鼠中进行抗癌效果测试时，BSA/AgNP 负载水凝胶薄膜的 PTT 单次治疗即可显著抑制肿瘤生长，且无明显毒性。
总体而言，本研究结果表明，负载 BSA/AgNP 的水凝胶薄膜可用作治疗皮肤癌的有效且安全的局部 PTT 制剂。
