Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, P. R. China.
J Sep Sci. 2021 Jun;44(12):2483-2495. doi: 10.1002/jssc.202100137. Epub 2021 May 3.
Molecularly imprinted polymers, developed 50 years ago, have garnered enormous attention as receptor-like materials. Lately, molecularly imprinted polymers have been employed as a specific target tool in favor of cancer diagnosis and therapy by the selective recognition of tumor cells. Although the molecular imprinting technology has been well-innovated recently, the cell still remains the most challenging target for imprinting. In this review, we summarize the advances in the synthesis of molecularly imprinted polymers suitable for the selective recognition of tumor cells. Through a sustained effort, three strategies have been developed including peptide-imprinting, polysaccharide-imprinting, and whole-cell imprinting, which have resulted in inspiring applications in effective cancer diagnosis and therapy. The major challenges and perspectives on the further directions related to the synthesis of molecularly imprinted polymers were also outlined.
分子印迹聚合物作为受体样材料，在 50 年前就已经引起了广泛关注。最近，分子印迹聚合物已被用作一种特定的靶向工具，通过对肿瘤细胞的选择性识别，用于癌症的诊断和治疗。尽管分子印迹技术最近得到了很好的创新，但细胞仍然是印迹的最具挑战性的目标。在这篇综述中，我们总结了适用于肿瘤细胞选择性识别的分子印迹聚合物的合成进展。通过持续的努力，已经开发出了三种策略，包括肽印迹、多糖印迹和全细胞印迹，这在有效的癌症诊断和治疗方面取得了令人鼓舞的应用。还概述了与分子印迹聚合物合成相关的进一步方向的主要挑战和前景。
