Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211800, P. R. China.
Adv Sci (Weinh). 2022 Oct;9(28):e2202038. doi: 10.1002/advs.202202038. Epub 2022 Jul 31.
Inspired by the recognition mechanism of biological molecules, molecular imprinting techniques (MITs) are imparted with numerous merits like excellent stability, recognition specificity, adsorption properties, and easy synthesis processes, and thus broaden the avenues for convenient fabrication protocol of bio-inspired molecularly imprinted polymers (MIPs) with desirable functions to satisfy the extensive demands of biomedical applications. Herein, the recent research progress made with respect to bio-inspired imprinting materials is discussed in this review. First, the underlying mechanism and basic components of a typical molecular imprinting procedure are briefly explored. Then, emphasis is put on the introduction of diverse MITs and novel bio-inspired imprinting materials. Following these two sections, practical applications of MIPs in the field of biomedical science are focused on. Last but not least, perspectives on the remaining challenges and future development of bio-inspired imprinting materials are presented.
受生物分子识别机制的启发,分子印迹技术(MITs)具有出色的稳定性、识别特异性、吸附性能和易于合成等优点,因此为方便制备具有理想功能的仿生分子印迹聚合物(MIPs)开辟了新途径,以满足广泛的生物医学应用需求。本文综述了近年来在仿生印迹材料方面的研究进展。首先,简要探讨了典型分子印迹过程的基本原理和基本组成部分。然后,重点介绍了各种 MITs 和新型仿生印迹材料。在这两个部分之后,重点介绍了 MIPs 在生物医学领域的实际应用。最后但同样重要的是,提出了对仿生印迹材料面临的挑战和未来发展的展望。