Kortesniemi Maaria, Slupsky Carolyn M, Aatsinki Anna-Katariina, Sinkkonen Jari, Karlsson Linnea, Linderborg Kaisa M, Yang Baoru, Karlsson Hasse, Kailanto Henna-Maria
Food Chemistry and Food Development, Department of Life Technologies, University of Turku, Finland; Department of Nutrition, University of California Davis, Davis, CA, USA.
Department of Nutrition, University of California Davis, Davis, CA, USA; Department of Food Science and Technology, University of California Davis, Davis, CA, USA.
Food Chem. 2021 Sep 15;356:129628. doi: 10.1016/j.foodchem.2021.129628. Epub 2021 Mar 20.
The composition of human milk is subject to considerable variation, but the effects of maternal stress are largely unknown. We studied differences in human milk metabolome between Finnish mothers (n = 120, secretors) with symptoms of prenatal symptoms of psychological distress and milk cortisol concentrations. Human milk samples acquired at 2.5 months postpartum were analyzed using targeted H NMR metabolomics. Self-reported scores for depression (EPDS), overall anxiety (SCL-90), and pregnancy-related anxiety (PRAQ) were used to evaluate psychological distress. Prenatal psychological distress was positively associated with concentrations of short-chain fatty acids, caprate, and hypoxanthine (q < 0.0012). Milk cortisol was positively associated with lactate concentration (q < 0.05). Changes in the human milk metabolome were shown to be associated with maternal psychological distress and concentration of milk cortisol in a dissimilarly, suggesting alterations in bacterial and energy metabolism of the mother, respectively.
母乳的成分存在很大差异，但母体压力的影响在很大程度上尚不清楚。我们研究了有产前心理困扰症状的芬兰母亲（n = 120，分泌型）的母乳代谢组与母乳皮质醇浓度之间的差异。使用靶向核磁共振代谢组学分析产后2.5个月采集的母乳样本。用自我报告的抑郁评分（爱丁堡产后抑郁量表）、总体焦虑评分（症状自评量表90项）和与妊娠相关的焦虑评分（妊娠相关焦虑量表）来评估心理困扰。产前心理困扰与短链脂肪酸、癸酸盐和次黄嘌呤的浓度呈正相关（q < 0.0012）。母乳皮质醇与乳酸浓度呈正相关（q < 0.05）。母乳代谢组的变化分别与母体心理困扰和母乳皮质醇浓度相关，表明母亲的细菌代谢和能量代谢发生了改变。
