Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
DNA Repair (Amst). 2021 Jun;102:103105. doi: 10.1016/j.dnarep.2021.103105. Epub 2021 Mar 24.
Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents which has the survival rate of 20% in its advanced stages. Osteosarcomas are mostly resistance to our common treatments. DNA damage response (DDR) is a specialized multistep process containing abundant proteins which are necessary for the survival of any cell and organism. DDR machinery detects a diversity of DNA lesions and inhibits the cell cycle progression if these lesions are not repairable. DDR is involved in aging, age-related diseases, and cancer. In recent years, DDR inhibitors have gained the attention of researches due to their potentials in offering novel therapeutic targets and improving the response of many cancers to either chemo- or radio-therapy. In this regard, we tried to gather a great body of evidence about the role of DDR ingredients in osteosarcoma's initiation/progression, prognosis, and treatment.
骨肉瘤（OS）是儿童和青少年中最常见的原发性骨恶性肿瘤，其晚期的存活率为 20%。骨肉瘤对我们常用的治疗方法大多具有耐药性。DNA 损伤反应（DDR）是一个专门的多步骤过程，包含大量对任何细胞和生物体的生存都必不可少的蛋白质。DDR 机制可以检测多种 DNA 损伤，并在这些损伤无法修复时抑制细胞周期进程。DDR 与衰老、与年龄相关的疾病和癌症有关。近年来，DDR 抑制剂因其在提供新的治疗靶点和提高许多癌症对化疗或放疗的反应方面的潜力而引起了研究人员的关注。在这方面，我们试图收集大量证据，说明 DDR 成分在骨肉瘤的发生/进展、预后和治疗中的作用。
