Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, London, United Kingdom.
Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom; Asthma UK Centre for Allergic Mechanisms in Asthma, King's College London, London, United Kingdom; NIHR Biomedical Centre at Guy's and St Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
Early Hum Dev. 2021 Jun;157:105353. doi: 10.1016/j.earlhumdev.2021.105353. Epub 2021 Mar 17.
Discharge home of preterm infants on supplemental oxygen has significant healthcare, parental psychological and financial implications, but the potential ability of clinical parameters at discharge to predict the duration of home oxygen has not been previously examined.
To use clinical and epidemiological parameters available at discharge to predict the duration of home oxygen therapy.
Retrospective observational cohort study with a primary and a validation cohort.
Seventy one infants born <32 completed weeks of gestational age, born between 1/1/2013-1/1/2020 at King's College Hospital NHS Foundation trust and discharged home on supplemental oxygen were studied.
Duration of home oxygen therapy.
In a primary cohort of 52 infants with a median (IQR) gestational age of 26.4 (25.0-28.1) weeks and birth weight of 0.81 (0.69-0.96) kg, the duration of home oxygen was four (3-7) months (range: 1-22 months). The postmenstrual age (adjusted p = 0.001) and oxygen flow at discharge (adjusted p = 0.046) were independently associated with the duration of home oxygen therapy. In a validation cohort of 19 infants, the correlation coefficient between the calculated and the observed duration of home oxygen was 0.62, p = 0.005 and the coefficient of determination was 0.38.
Infants discharged home on higher oxygen flows and at a greater postmenstrual age require a longer duration of home oxygen therapy and these parameters can be used to predict the duration of home oxygen therapy.
早产儿出院时使用补充氧气会对医疗保健、父母心理和经济产生重大影响，但临床参数在出院时预测家庭氧疗持续时间的潜在能力尚未被研究过。
利用出院时可用的临床和流行病学参数预测家庭氧疗的持续时间。
具有主要和验证队列的回顾性观察队列研究。
71 名出生于<32 周的胎龄、2013 年 1 月 1 日至 2020 年 1 月 1 日期间在英国国王学院医院 NHS 基金会信托出生、出院时在家中接受补充氧气的婴儿被纳入研究。
家庭氧疗的持续时间。
在一个包含 52 名婴儿的主要队列中，中位数（IQR）胎龄为 26.4（25.0-28.1）周，出生体重为 0.81（0.69-0.96）kg，家庭氧疗持续时间为 4（3-7）个月（范围：1-22 个月）。校正后的胎龄（调整后的 p=0.001）和出院时的氧气流量（调整后的 p=0.046）与家庭氧疗持续时间独立相关。在一个包含 19 名婴儿的验证队列中，计算的和观察的家庭氧疗持续时间之间的相关系数为 0.62，p=0.005，决定系数为 0.38。
出院时使用更高氧气流量和更大胎龄的婴儿需要更长时间的家庭氧疗，这些参数可用于预测家庭氧疗的持续时间。
