载脂蛋白基因多态性与高脂血症的关联：一项荟萃分析。

Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis.

机构信息

School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, China.

School of Public Health, Hebei Medical University, Shijiazhuang, 050017, China.

出版信息

BMC Genom Data. 2021 Apr 9;22(1):14. doi: 10.1186/s12863-021-00968-1.

BACKGROUND

Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions.

RESULTS

A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5-1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05.

CONCLUSIONS

Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

背景

高脂血症在心脑血管疾病的病因学中起着重要作用。近年来，许多研究探讨了载脂蛋白遗传多态性对高脂血症的影响，但在不同地区不同人群的相关性研究中发现了相当大的差异和不确定性。

结果

共纳入 59 篇文章，其中病例组共纳入 13843 例高脂血症患者，对照组共纳入 15398 例健康对照。数据分析的荟萃分析表明，APOA5-1131T>C、APOA1-75bp、APOB XbaI 和 APOE 基因多态性与高脂血症显著相关，OR 值分别为 1.996、1.228、1.444 和 1.710，所有 P 值均小于 0.05。