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妊娠期肾肿瘤的处理:病例报告。

Management of renal tumors during pregnancy: case reports.

机构信息

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Science, Beijing, China.

Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

出版信息

BMC Nephrol. 2021 Apr 9;22(1):127. doi: 10.1186/s12882-021-02318-w.

DOI:10.1186/s12882-021-02318-w
PMID:33836679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8035726/
Abstract

BACKGROUND

Renal tumors during pregnancy are rare and the treatment requires evaluation of both the patient and the fetus. No consensus or guidelines has been proposed or verified in this field. We successfully managed three renal tumor cases during pregnancy and reviewed the relative literature.

CASE PRESENTATION

In the first renal cell carcinoma case diagnosed in the 21st week of pregnancy, laparoscopic retroperitoneoscopic partial nephrectomy was performed in the 26th week of pregnancy. In the second renal cell carcinoma case diagnosed in the 3rd week of pregnancy, laparoscopic retroperitoneoscopic radical nephrectomy was carried out after the abortion. In the third angiomyolipoma case who was diagnosed before pregnancy but received no treatment, we performed laparoscopic retroperitoneoscopic partial nephrectomy during the 17th week of pregnancy due to the rapid enlargement of the tumor.

CONCLUSION

Although no consensus or guidelines for the management of renal tumors in pregnant patients has been proposed or verified, the general rules of kidney tumor management in non-pregnant patients and the guidelines for surgery in pregnancy could be referred to. Renal tumors found in pregnant patients require an individualized treatment regimen involving surgical timing, routes, techniques, and excision ranges, which should be decided by both the patients and the surgical teams.

摘要

背景

妊娠期间的肾脏肿瘤较为罕见,其治疗需要同时评估患者和胎儿的情况。目前在该领域尚未提出或验证任何共识或指南。我们成功管理了 3 例妊娠期间的肾脏肿瘤病例,并复习了相关文献。

病例介绍

在妊娠 21 周诊断出的首例肾细胞癌病例中,我们在妊娠 26 周时进行了腹腔镜后腹腔镜肾部分切除术。在妊娠第 3 周诊断出的第 2 例肾细胞癌病例中,在流产后进行了腹腔镜后腹腔镜根治性肾切除术。在第 3 例血管平滑肌脂肪瘤病例中,该病例在妊娠前诊断出但未进行治疗,由于肿瘤迅速增大,我们在妊娠第 17 周时进行了腹腔镜后腹腔镜肾部分切除术。

结论

虽然尚未提出或验证针对妊娠患者肾脏肿瘤处理的共识或指南,但可以参考非妊娠患者的肾脏肿瘤处理一般原则和妊娠手术指南。对于妊娠期间发现的肾脏肿瘤,需要制定个体化的治疗方案,包括手术时机、途径、技术和切除范围,应由患者和手术团队共同决定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/8035726/202bada020dd/12882_2021_2318_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/8035726/202bada020dd/12882_2021_2318_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0392/8035726/202bada020dd/12882_2021_2318_Fig1_HTML.jpg

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Int J Surg Case Rep. 2025 Jun 11;133:111483. doi: 10.1016/j.ijscr.2025.111483.
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Robotic Surgery in the Management of Renal Tumors During Pregnancy: A Narrative Review.孕期肾肿瘤管理中的机器人手术:一项叙述性综述
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Renal Cell Carcinoma in Pregnancy: A Case Report of a Rare Diagnosis.

本文引用的文献

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Evidence-Based Guideline on Laparoscopy in Pregnancy: Commissioned by the British Society for Gynaecological Endoscopy (BSGE) Endorsed by the Royal College of Obstetricians & Gynaecologists (RCOG).《妊娠期腹腔镜检查循证指南》:由英国妇科内镜学会(BSGE)委托编写,经皇家妇产科医师学院(RCOG)认可。
Facts Views Vis Obgyn. 2019 Mar;11(1):5-25.
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NCCN Guidelines Insights: Kidney Cancer, Version 2.2020.NCCN 指南解读:肾癌,第 2.2020 版。
J Natl Compr Canc Netw. 2019 Nov 1;17(11):1278-1285. doi: 10.6004/jnccn.2019.0054.
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Laparoscopic Approach in Management of Renal Cell Carcinoma During Pregnancy: State of the Art.
妊娠期肾细胞癌:一例罕见诊断的病例报告。
Cureus. 2025 Jan 5;17(1):e76960. doi: 10.7759/cureus.76960. eCollection 2025 Jan.
4
Eosinophilic Variant of Chromophobe Renal Cell Carcinoma During Pregnancy: A Multidisciplinary Approach and Successful Management in a Tertiary Hospital in Mexico.孕期嫌色性肾细胞癌的嗜酸性粒细胞变体:墨西哥一家三级医院的多学科方法及成功管理
Cureus. 2023 Sep 9;15(9):e44955. doi: 10.7759/cureus.44955. eCollection 2023 Sep.
腹腔镜手术在妊娠合并肾细胞癌治疗中的应用:现状。
Clin Genitourin Cancer. 2019 Aug;17(4):e822-e830. doi: 10.1016/j.clgc.2019.05.025. Epub 2019 May 27.
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Renal cell carcinoma diagnosed during pregnancy: a case report and literature review.妊娠期诊断出的肾细胞癌:一例病例报告及文献综述
J Int Med Res. 2018 Aug;46(8):3422-3426. doi: 10.1177/0300060518776744. Epub 2018 Jun 8.
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An update on recent developments in rupture of renal angiomyolipoma.肾血管平滑肌脂肪瘤破裂的近期进展更新
Medicine (Baltimore). 2018 Apr;97(16):e0497. doi: 10.1097/MD.0000000000010497.
6
Renal angiomyolipoma during pregnancy: Case report and literature review.妊娠期肾血管平滑肌脂肪瘤:病例报告及文献复习
Turk J Obstet Gynecol. 2015 Jun;12(2):118-121. doi: 10.4274/tjod.32848. Epub 2015 Jun 15.
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Selective arterial embolization of symptomatic and asymptomatic renal angiomyolipomas: a retrospective study of safety, outcomes and tumor size reduction.有症状和无症状肾血管平滑肌脂肪瘤的选择性动脉栓塞术:一项关于安全性、疗效及肿瘤缩小情况的回顾性研究
Quant Imaging Med Surg. 2017 Feb;7(1):8-23. doi: 10.21037/qims.2017.01.02.
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Spontaneous rupture of renal angiomyolipoma during pregnancy.妊娠期肾血管平滑肌脂肪瘤自发性破裂。
BMJ Case Rep. 2017 Jan 6;2017:bcr2016217284. doi: 10.1136/bcr-2016-217284.
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Laparoscopic Partial Nephrectomy for Renal-Cell Carcinoma During Pregnancy.孕期腹腔镜下肾部分切除术治疗肾细胞癌
J Endourol Case Rep. 2016 Feb 1;2(1):18-20. doi: 10.1089/cren.2015.0012. eCollection 2016.
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