Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, 8440 112 St. NW, Edmonton, AB, T6G 2R7, Canada.
Orphanet J Rare Dis. 2021 Apr 9;16(1):168. doi: 10.1186/s13023-021-01804-6.
With the advancements in genetics and genomics in the twenty-first century, genetic services have become an integral part of medical practices in high-income and upper-middle-income countries. However, people living in low and lower-middle-income countries (LICs and LIMCs), including Bangladesh, are rather underprivileged in receiving genetic services. Consequently, genetic disorders are emerging as a significant public health concern in these countries. Lack of expertise, high expense, the dearth of epidemiological data, insufficiently updated medical education system, poor infrastructure, and the absence of comprehensive health policies are the main factors causing people living in these countries not having access to genetic services. In this article, the authors took benefit from their professional experience of practicing medical genetics in the area and reviewed existing literature to provide their opinions. Particularly, it reviews the current knowledge of genetic disorders' burden and their causative factors in Bangladesh. It focuses on why providing genetic services is challenging in the context of the country's cultural and religious sentiment. Finally, it proposes a physician-academician collaborative framework within the existing facility that aims to tackle the challenges. Such a framework could also be useful for other LICs and LMICs to address the challenges associated with providing genetic services.
随着二十一世纪遗传学和基因组学的进步,遗传服务已成为高收入和中上收入国家医疗实践不可或缺的一部分。然而,包括孟加拉国在内的低收入和中低收入国家(LIC 和 LIMC)的人民在获得遗传服务方面相当不利。因此,遗传疾病在这些国家成为一个重大的公共卫生关注点。缺乏专业知识、费用高昂、缺乏流行病学数据、医学教育系统更新不足、基础设施薄弱以及缺乏全面的卫生政策,是这些国家的人民无法获得遗传服务的主要因素。在本文中,作者利用他们在该地区从事医学遗传学的专业经验,并查阅了现有文献,提出了自己的观点。特别是,它回顾了孟加拉国遗传疾病负担及其致病因素的现有知识。它重点讨论了为什么在国家文化和宗教情感背景下提供遗传服务具有挑战性。最后,它提出了一个在现有设施内的医师-学者合作框架,旨在应对这些挑战。该框架对于其他 LIC 和 LMIC 解决提供遗传服务相关的挑战也可能具有一定的参考价值。