Department of Psychology and Human Development, University College London, London WC1H 0AA, United Kingdom.
Department of Psychology and Human Development, University College London, London WC1H 0AA, United Kingdom.
Schizophr Res. 2021 May;231:108-114. doi: 10.1016/j.schres.2021.03.016. Epub 2021 Apr 8.
Psychopathology in childhood and adolescence, commonly indexed by co-occurring internalizing and externalizing problem behaviors, has been found to predict psychotic-like experiences (PLEs) in adults. However, studies to date have rarely examined internalizing and externalizing problem behaviors simultaneously or identified in which developmental period do these problem behaviors predict PLEs in adults. This study tests to what extent internalizing and externalizing problem behaviors in childhood (4-9 years) or adolescence (11-16 years) predict PLEs in young-adulthood (18 years).
Parent-rated child internalizing and externalizing problems on the Strengths and Difficulties Questionnaire at ages 4, 6, 8, 9, 11, 13, and 16 years from the Avon Longitudinal Study of Parents and Children (N = 4717) were modelled using two-piece latent growth curve modelling to predict clinician-rated PLEs at age 18 years, controlling for confounders (gender, ethnicity, socio-economic status, parental education and stressful life events) assessed prior to baseline at age 4 years.
Controlling for confounders, an increase in childhood internalizing problems from 4 to 9 years and externalizing problems at baseline (at 4 years) predicted PLEs at 18 years, explaining 9.5% of the variance in adult PLEs. These associations were independent to controls for any changes in adolescent internalizing and externalizing problems from 11 to 16 years.
High baseline levels of externalizing problems and increasing internalizing problems throughout childhood can predict PLEs at 18 years. Externalizing problems around the transition to primary school and internalizing problems throughout childhood may be particularly helpful in informing risk of PLEs in young-adulthood.
儿童和青少年时期的精神病理学,通常表现为同时存在的内化和外化问题行为,已被发现可预测成人期类似精神病的体验(PLEs)。然而,迄今为止的研究很少同时检查内化和外化问题行为,也没有确定这些问题行为在哪个发育阶段可预测成人期的 PLEs。本研究检验了儿童期(4-9 岁)或青春期(11-16 岁)的内化和外化问题行为在多大程度上可预测成年早期(18 岁)的 PLEs。
使用两段式潜增长曲线模型,从阿冯纵向研究父母和儿童(N=4717)中,以年龄 4、6、8、9、11、13 和 16 岁时父母对儿童的内化和外化问题的评分,来预测年龄 18 岁时临床医生评定的 PLEs,同时控制在基线前(4 岁时)评估的混杂因素(性别、种族、社会经济地位、父母教育和生活压力事件)。
控制混杂因素后,4 岁到 9 岁期间内化问题的增加和基线(4 岁时)的外化问题预测了 18 岁时的 PLEs,解释了成人 PLEs 方差的 9.5%。这些关联独立于青少年期 11 岁到 16 岁期间内化和外化问题的任何变化的控制。
基线水平较高的外化问题和整个儿童期内化问题的增加可预测 18 岁时的 PLEs。小学过渡时期的外化问题和整个儿童期的内化问题可能特别有助于预测成年早期的 PLEs 风险。