Wermuth L
Department of Neurology, University Hospital, Odense, Denmark.
Eur Neurol. 1988;28(3):152-5. doi: 10.1159/000116254.
A retrospective study of the treatment of 148 patients with severe parkinsonism is reported. After dopa preparation was introduced as a treatment for Parkinson's disease the progress of the disease has changed. More patients with first signs after 1970 had mild progression of disease compared to patients with a debut before 1970. In addition, the population with manifestations after 1970 had fewer cases of severe progression. Adverse effects of dopa treatment had been observed in 70% of the patients. After 5 years of treatment with dopa preparation, 62.1% of the patients had momentary peak-dose dyskinesia. After 2 years of treatment 14.2% of the patients had on-off effects with higher incidence after further treatment. One hundred and fifteen patients have been treated with bromocriptine, 27 patients for more than 5 years.
报告了一项对148例严重帕金森病患者治疗情况的回顾性研究。自从将多巴制剂引入帕金森病治疗后，该病的进展情况发生了变化。与1970年之前首次出现症状的患者相比，1970年之后首次出现症状的患者中，病情呈轻度进展的更多。此外，1970年之后出现症状的人群中，严重病情进展的病例较少。70%的患者观察到了多巴治疗的不良反应。在使用多巴制剂治疗5年后，62.1%的患者出现了瞬间峰值剂量异动症。治疗2年后，14.2%的患者出现了开关现象，继续治疗后发病率更高。115例患者接受了溴隐亭治疗，其中27例治疗时间超过5年。
