Schubert J, Kelly L U, Wehnert J, Moravek P
Urologic Clinic, Medical Academy Carl Gustav Carus, Dresden, GDR.
Eur Urol. 1988;14(3):196-201. doi: 10.1159/000472936.
A total of 181 prostatic cancer patients under radiation monotherapy were tested for the therapeutic effect of pelvic lymphadenectomy (PLA). Sixty-seven belonging to the pN0 category formed a highly selective group and presented a 89% rate of 7-year survival. Localized radiation therapy with pelvic irradiation (81 patients) with conventional exclusion of lymphogenic macrometastases in the probable presence of micrometastases produced equally good results. Extended pelvic irradiation in cases of conventionally verified regional lymphogenic macrometastases remained without therapeutic effect. The combination of PLA with pelvic irradiation, when regional metastases have already occurred (23 patients), may be suited for localizing the tumor process, since the survival rates showed no significant difference compared to those of the pN0 group. For that reason and also because of the difficulty in determining the N category accurately by conventional methods, it is recommended to perform PLA prior to radiation monotherapy.
对181例接受单纯放疗的前列腺癌患者进行了盆腔淋巴结清扫术（PLA）的治疗效果测试。67例属于pN0类别的患者组成了一个高度选择性的组，其7年生存率为89%。对81例患者进行盆腔照射的局部放疗，在可能存在微转移的情况下常规排除淋巴源性大转移，也取得了同样好的效果。在经传统方法证实存在区域淋巴源性大转移的情况下进行扩大盆腔照射仍无治疗效果。当区域转移已经发生时（23例患者），PLA与盆腔照射联合使用可能适合于定位肿瘤进程，因为与pN0组相比，生存率没有显著差异。基于这个原因，也因为用传统方法准确确定N类别存在困难，建议在单纯放疗前进行PLA。
