Qiu Weiwang, Han Hua, Li Mengna, Li Na, Wang Qian, Qin Xiaohong, Wang Xueli, Yu Jianyong, Zhou Yunxia, Li Yan, Li Faxue, Wu Dequn
Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.
Innovation Center for Textile Science and Technology, Donghua University, Shanghai 200051, China.
J Colloid Interface Sci. 2021 Aug 15;596:312-323. doi: 10.1016/j.jcis.2021.02.107. Epub 2021 Mar 10.
The chronic wounds often hinder wound healing resulting from infection; thus, an ideal wound dressing should be able to maintain a healthy wound microenvironment. Herein, peptide modified nanofibers reinforced hydrogel has been designed by Schiff base dynamic crosslinking. The incorporation of the nanofibers into the hydrogel extremely enhances the stability and mechanical strength of the hydrogel. Taking advantage of the feature, the reinforced hydrogel can restore its original shape while suffering the various external forces on the hydrogel-covered irregular shape wounds. The peptide modified nanofibers reinforced hydrogel (NFRH) not only possesses injectable and self-healing properties, but also inherent antibacterial and hemostatic properties, which can eradicate the bacterial biofilms and induce blood cells and platelets aggregation and finally accelerate the chronic wound healing process. The peptide modified nanofibers reinforced hydrogel has enormous potential to be novel dressing for chronic wounds healing clinically.
慢性伤口常常因感染而阻碍伤口愈合；因此，理想的伤口敷料应能够维持健康的伤口微环境。在此，通过席夫碱动态交联设计了肽修饰的纳米纤维增强水凝胶。将纳米纤维掺入水凝胶中极大地提高了水凝胶的稳定性和机械强度。利用这一特性，增强水凝胶在覆盖不规则形状伤口的水凝胶遭受各种外力时能够恢复其原始形状。肽修饰的纳米纤维增强水凝胶（NFRH）不仅具有可注射和自愈特性，还具有固有的抗菌和止血特性，能够根除细菌生物膜并诱导血细胞和血小板聚集，最终加速慢性伤口愈合过程。肽修饰的纳米纤维增强水凝胶具有巨大潜力，有望成为临床上用于慢性伤口愈合的新型敷料。
