Amendola Vincenzo, Guadagnini Andrea, Agnoli Stefano, Badocco Denis, Pastore Paolo, Fracasso Giulio, Gerosa Marco, Vurro Federica, Busato Alice, Marzola Pasquina
Department of Chemical Sciences, University of Padova, Padova I-35131, Italy.
Department of Chemical Sciences, University of Padova, Padova I-35131, Italy.
J Colloid Interface Sci. 2021 Aug 15;596:332-341. doi: 10.1016/j.jcis.2021.03.096. Epub 2021 Mar 19.
Bimetallic nanoparticles allow new and synergistic properties compared to the monometallic equivalents, often leading to unexpected results. Here we present on silver-iron nanoparticles coated with polyethylene glycol, which exhibit a high transverse relaxivity (316 ± 13 mMs, > 3 times that of the most common clinical benchmark based on iron oxide), excellent colloidal stability and biocompatibility in vivo. Ag-Fe nanoparticles are obtained through a one-step, low-cost laser-assisted synthesis, which makes surface functionalization with the desired biomolecules very easy. Besides, Ag-Fe nanoparticles show biodegradation over a few months, as indicated by incubation in the physiological environment. This is crucial for nanomaterials removal from the living organism and, in fact, in vivo biodistribution studies evidenced that Ag-Fe nanoparticles tend to be cleared from liver over a period in which the benchmark iron oxide contrast agent persisted. Therefore, the Ag-Fe NPs offer positive prospects for solving the problems of biopersistence, contrast efficiency, difficulties of synthesis and surface functionalization usually encountered in nanoparticulate contrast agents.
与单金属纳米粒子相比，双金属纳米粒子具有新的协同特性，常常会带来意想不到的结果。在此，我们展示了包覆聚乙二醇的银铁纳米粒子，其横向弛豫率很高（316±13 mM⁻¹s⁻¹，比最常用的基于氧化铁的临床基准高出3倍以上），在体内具有出色的胶体稳定性和生物相容性。银铁纳米粒子通过一步低成本激光辅助合成获得，这使得用所需生物分子进行表面功能化变得非常容易。此外，如在生理环境中孵育所示，银铁纳米粒子在几个月内会发生生物降解。这对于从生物体中去除纳米材料至关重要，事实上，体内生物分布研究表明，在基准氧化铁造影剂持续存在期间，银铁纳米粒子往往会在一段时间内从肝脏中清除。因此，银铁纳米粒子为解决纳米颗粒造影剂通常遇到的生物持久性、造影效率、合成困难和表面功能化问题提供了积极的前景。
