Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.
German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Eur J Nutr. 2021 Oct;60(7):3811-3818. doi: 10.1007/s00394-021-02521-3. Epub 2021 Apr 11.
Recent trials demonstrated remission of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) following formula diet-induced weight loss. To improve the outreach for populations in need, many mobile health apps targeting weight loss have been developed with limited scientific evaluation of these apps. The present feasibility study investigated the effects of a novel approach incorporating a regular 'whole food-based' low-calorie diet combined with app-based digital education and behavioral change program on glucose metabolism and disease management.
Twenty-four individuals with type 2 diabetes followed this approach supported by weekly coaching calls for 12 weeks. Phenotyping included bioimpedance analysis, mixed-meal tolerance test, magnetic resonance spectroscopy and transient elastography for assessing liver fat content and liver stiffness.
Over 12 weeks, participants reduced their body weight by 9% (97 ± 13 to 88 ± 12 kg), body mass index (BMI; 33 ± 5 to 29 ± 4 kg/m), total fat mass (31 ± 10 to 27 ± 10%) (all p < 0.01) and liver fat by 50% alongside with decreased liver stiffness. Target HbA1c (< 6.5%) was achieved by 38% and resolution of NAFLD (liver fat content < 5.6%) was observed in 30% of the participants.
This novel approach combining digital education with a low-calorie diet results in effective improvements of body weight, glycemic control and NAFLD and could complement existing care for patients with type 2 diabetes.
NCT04509245.
最近的试验表明，通过配方饮食诱导的体重减轻可以缓解 2 型糖尿病和非酒精性脂肪性肝病（NAFLD）。为了扩大有需要的人群的受益面，许多针对减肥的移动健康应用程序已经开发出来，但这些应用程序的科学评估有限。本可行性研究调查了一种新方法的效果，该方法将常规的“全食物基础”低热量饮食与基于应用程序的数字教育和行为改变计划相结合，对葡萄糖代谢和疾病管理产生影响。
24 例 2 型糖尿病患者采用这种方法，在 12 周内每周接受一次电话咨询。表型分析包括生物阻抗分析、混合餐耐量试验、磁共振波谱和瞬态弹性成像，以评估肝脂肪含量和肝硬度。
在 12 周内，参与者的体重减轻了 9%（97±13 至 88±12 千克），体重指数（BMI；33±5 至 29±4 千克/米），总脂肪量（31±10 至 27±10%）（均 p<0.01），肝脂肪减少了 50%，同时肝硬度降低。38%的患者达到了目标 HbA1c（<6.5%），30%的患者实现了 NAFLD（肝脂肪含量<5.6%）的缓解。
这种将数字教育与低热量饮食相结合的新方法可有效改善体重、血糖控制和 NAFLD，可作为 2 型糖尿病患者现有治疗方法的补充。
NCT04509245。
