Antimicrobial Resistance Unit, National Institute for Health and Welfare, Kiinamyllynkatu 13, 20520, Turku, Finland.
Eur J Clin Microbiol Infect Dis. 2012 May;31(5):703-6. doi: 10.1007/s10096-011-1361-4. Epub 2011 Jul 30.
The rapid detection of carriage of Streptococcus pneumoniae could assist in the management of pneumococcal infection, such as acute otitis media. We evaluated the reliability of the Binax NOW test in the exclusion and detection of pneumococcal carriage by nasal samples from 139 children and using nasopharyngeal samples from 250 children (aged 6-35 months) with respiratory infection with or without acute otitis media. The Binax NOW test results were compared with culture-based detection of carriage of S. pneumoniae. The Binax NOW test from the nasal samples had a sensitivity of 95%, a specificity of 78%, and the positive and negative predictive values were 83 and 93%, respectively; and for the nasopharyngeal samples the corresponding numbers were 88%, 95%, 96%, and 87%. When rapid knowledge of the carriage status of S. pneumoniae is needed, the Binax NOW test is a reliable method for the exclusion of carriage using nasal sampling, and in the detection of carriage using nasopharyngeal sampling.
快速检测肺炎链球菌携带情况有助于管理肺炎链球菌感染，例如急性中耳炎。我们评估了 Binax NOW 试验在排除和检测鼻咽拭子中肺炎链球菌携带的可靠性，该研究纳入了 139 名患有呼吸道感染（伴或不伴急性中耳炎）的 6-35 月龄儿童，同时纳入了 250 名儿童的鼻咽拭子样本。将 Binax NOW 试验结果与基于培养的肺炎链球菌携带检测进行了比较。鼻拭子的 Binax NOW 试验的敏感性为 95%，特异性为 78%，阳性预测值和阴性预测值分别为 83%和 93%；鼻咽拭子的相应数值分别为 88%、95%、96%和 87%。当需要快速了解肺炎链球菌携带状态时，Binax NOW 试验是一种可靠的方法，可通过鼻采样排除携带，也可通过鼻咽采样检测携带。
