Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Value Health. 2021 Apr;24(4):539-547. doi: 10.1016/j.jval.2020.10.002. Epub 2020 Nov 28.
Health economics analysis plans (HEAPs) currently lack consistency, with uncertainty surrounding appropriate content. We aimed to develop a list of essential items that should be included in HEAPs for economic evaluations conducted alongside randomized trials.
A list of potential items for inclusion was developed by examining existing HEAPs. An electronic Delphi survey was conducted among professional health economists. Respondents were asked to rate potential items from 1 (least important) to 9 (most important), suggest additional items, and comment on proposed items (round 1). A second survey (round 2) was emailed to participants, including the participant's own scores from round 1 along with summary results from the whole panel; participants were asked to rerate each item. Consensus criteria for inclusion in the final list were predefined as >70% of participants rating an item 7-9 and <15% rating it 1-3 after round 2. A final item selection meeting was held to scrutinize the results and adjudicate on items lacking consensus.
62 participants completed round 1 of the survey. The initial list included 72 potential items; all 72 were carried forward to round 2, and no new items were added. 48 round 1 respondents (77.4%) completed round 2 and reached consensus on 53 items. At the final meeting, the expert panel (n = 9) agreed that 58 items should be included in the essential list, moved 9 items to an optional list, and dropped 5 items.
Via expert consensus opinion, this study identified 58 items that are considered essential in a HEAP.
健康经济学分析计划（HEAPs）目前缺乏一致性，其内容也存在不确定性。我们旨在制定一份应包含在与随机试验同时进行的经济评估的 HEAP 中的基本项目清单。
通过检查现有的 HEAP，制定了一份潜在项目清单。对专业健康经济学家进行了电子德尔菲调查。要求受访者对潜在项目进行 1（最不重要）到 9（最重要）的评分，提出其他项目，并对提出的项目进行评论（第一轮）。第二轮向参与者发送电子邮件，其中包括参与者第一轮的个人得分以及整个小组的总结结果；要求参与者重新对每个项目进行评分。纳入最终清单的共识标准预先定义为 >70%的参与者对项目进行 7-9 评分，<15%的参与者对项目进行 1-3 评分。举行了最后一次项目选择会议，仔细审查结果并对缺乏共识的项目进行裁决。
62 名参与者完成了第一轮调查。初始清单包括 72 个潜在项目；第二轮全部保留了 72 个项目，没有添加新项目。第一轮的 48 名受访者（77.4%）完成了第二轮，有 53 个项目达成共识。在最后一次会议上，专家组（n=9）同意将 58 个项目列入基本清单，将 9 个项目移至可选清单，并删除 5 个项目。
通过专家的共识意见，本研究确定了 HEAP 中 58 个被认为是必不可少的项目。
